USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
IDO1-mediated tryptophan metabolism plays an important role in creating an immunosuppressive tumour microenvironment. Here, the authors show that deubiquitinase USP14 regulates immune suppression by inducing IDO1 stabilization and suggest USP14 as a potential therapeutic target to improve immunother...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33285-x |
| _version_ | 1811253518246346752 |
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| author | Dongni Shi Xianqiu Wu Yunting Jian Junye Wang Chengmei Huang Shuang Mo Yue Li Fengtian Li Chao Zhang Dongsheng Zhang Huizhong Zhang Huilin Huang Xin Chen Y. Alan Wang Chuyong Lin Guozhen Liu Libing Song Wenting Liao |
| author_facet | Dongni Shi Xianqiu Wu Yunting Jian Junye Wang Chengmei Huang Shuang Mo Yue Li Fengtian Li Chao Zhang Dongsheng Zhang Huizhong Zhang Huilin Huang Xin Chen Y. Alan Wang Chuyong Lin Guozhen Liu Libing Song Wenting Liao |
| author_sort | Dongni Shi |
| collection | DOAJ |
| description | IDO1-mediated tryptophan metabolism plays an important role in creating an immunosuppressive tumour microenvironment. Here, the authors show that deubiquitinase USP14 regulates immune suppression by inducing IDO1 stabilization and suggest USP14 as a potential therapeutic target to improve immunotherapy in colorectal cancer. |
| first_indexed | 2024-04-12T16:52:12Z |
| format | Article |
| id | doaj.art-da0e7849fcb34a24976064852f9e4e8c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T16:52:12Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-da0e7849fcb34a24976064852f9e4e8c2022-12-22T03:24:21ZengNature PortfolioNature Communications2041-17232022-09-0113111810.1038/s41467-022-33285-xUSP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancerDongni Shi0Xianqiu Wu1Yunting Jian2Junye Wang3Chengmei Huang4Shuang Mo5Yue Li6Fengtian Li7Chao Zhang8Dongsheng Zhang9Huizhong Zhang10Huilin Huang11Xin Chen12Y. Alan Wang13Chuyong Lin14Guozhen Liu15Libing Song16Wenting Liao17Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen UniversityDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Pathology, Sun Yat-sen University Cancer CenterDepartment of Medical Oncology, Sun Yat-sen University Cancer CenterDepartment of Pathology, Sun Yat-sen University Cancer CenterDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineKey Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Institute of Oncology, Tumor Hospital, Guangzhou Medical UniversityBrown Center for Immunotherapy, Department of Medicine, Indiana University School of Medicine, Indiana University Melvin and Bren Simon Comprehensive Cancer CenterDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSchool of Life and Health Sciences, The Chinese University of Hong KongDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineIDO1-mediated tryptophan metabolism plays an important role in creating an immunosuppressive tumour microenvironment. Here, the authors show that deubiquitinase USP14 regulates immune suppression by inducing IDO1 stabilization and suggest USP14 as a potential therapeutic target to improve immunotherapy in colorectal cancer.https://doi.org/10.1038/s41467-022-33285-x |
| spellingShingle | Dongni Shi Xianqiu Wu Yunting Jian Junye Wang Chengmei Huang Shuang Mo Yue Li Fengtian Li Chao Zhang Dongsheng Zhang Huizhong Zhang Huilin Huang Xin Chen Y. Alan Wang Chuyong Lin Guozhen Liu Libing Song Wenting Liao USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer Nature Communications |
| title | USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer |
| title_full | USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer |
| title_fullStr | USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer |
| title_full_unstemmed | USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer |
| title_short | USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer |
| title_sort | usp14 promotes tryptophan metabolism and immune suppression by stabilizing ido1 in colorectal cancer |
| url | https://doi.org/10.1038/s41467-022-33285-x |
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