Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly Patients
Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators were involved in the pathogenesis of atherosclerosis. This study sought to investigate the effects of proatherogenic inflammatory and antiatherogenic inflammatory mediators on the proximal, middle, and distal corona...
| Main Authors: | , , , , |
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| 格式: | Article |
| 語言: | English |
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Hindawi Limited
2020-01-01
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| 叢編: | Mediators of Inflammation |
| 在線閱讀: | http://dx.doi.org/10.1155/2020/1719279 |
| _version_ | 1827085260456722432 |
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| author | Xia Li Dianxuan Guo Ying Chen Youdong Hu Fenglin Zhang |
| author_facet | Xia Li Dianxuan Guo Ying Chen Youdong Hu Fenglin Zhang |
| author_sort | Xia Li |
| collection | DOAJ |
| description | Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators were involved in the pathogenesis of atherosclerosis. This study sought to investigate the effects of proatherogenic inflammatory and antiatherogenic inflammatory mediators on the proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations. We measured the expression levels of proatherogenic inflammatory/antiatherogenic inflammatory cytokines. This included interleukin-1 β (IL-1 β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10), interleukin-17 (IL-17), interleukin-13 (IL-13), and interleukin-37 (IL-37) in the elderly patients with the proximal, middle, and distal coronary artery reocclusions after coronary stent implantations. Levels of IL-1 β, IL-6, IL-8, TNF-α, and hs-CRP were remarkably increased (P<0.001), and levels of IL-10, IL-17, IL-13, and IL-37 were remarkably lowered (P<0.001) in the elderly patients with the proximal, middle, and distal coronary artery reocclusions. Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators may be involved in the formation and progression of proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations. |
| first_indexed | 2025-03-20T04:18:06Z |
| format | Article |
| id | doaj.art-da0f3f05a8b34f16a0bd54c5b7ef84d4 |
| institution | Directory Open Access Journal |
| issn | 0962-9351 1466-1861 |
| language | English |
| last_indexed | 2025-03-20T04:18:06Z |
| publishDate | 2020-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj.art-da0f3f05a8b34f16a0bd54c5b7ef84d42024-10-03T05:50:18ZengHindawi LimitedMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/17192791719279Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly PatientsXia Li0Dianxuan Guo1Ying Chen2Youdong Hu3Fenglin Zhang4Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, ChinaDepartment of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, ChinaDepartment of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, ChinaDepartment of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, ChinaDepartment of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, ChinaImbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators were involved in the pathogenesis of atherosclerosis. This study sought to investigate the effects of proatherogenic inflammatory and antiatherogenic inflammatory mediators on the proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations. We measured the expression levels of proatherogenic inflammatory/antiatherogenic inflammatory cytokines. This included interleukin-1 β (IL-1 β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10), interleukin-17 (IL-17), interleukin-13 (IL-13), and interleukin-37 (IL-37) in the elderly patients with the proximal, middle, and distal coronary artery reocclusions after coronary stent implantations. Levels of IL-1 β, IL-6, IL-8, TNF-α, and hs-CRP were remarkably increased (P<0.001), and levels of IL-10, IL-17, IL-13, and IL-37 were remarkably lowered (P<0.001) in the elderly patients with the proximal, middle, and distal coronary artery reocclusions. Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators may be involved in the formation and progression of proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations.http://dx.doi.org/10.1155/2020/1719279 |
| spellingShingle | Xia Li Dianxuan Guo Ying Chen Youdong Hu Fenglin Zhang Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly Patients Mediators of Inflammation |
| title | Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly Patients |
| title_full | Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly Patients |
| title_fullStr | Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly Patients |
| title_full_unstemmed | Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly Patients |
| title_short | Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly Patients |
| title_sort | effects of altered levels of pro and anti inflammatory mediators on locations of in stent reocclusions in elderly patients |
| url | http://dx.doi.org/10.1155/2020/1719279 |
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