Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity
This work describes the fabrication of a carbazole derivative 1 namely (E)-5-(diethylamino)-2-((9-ethyl-9H-carbazol-3-yl)imino)methyl)phenol(1) based colorimetric probe for the selective detection of copper (II) ions. The as-prepared carbazole derivative was characterized using various spectral tech...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623003806 |
| _version_ | 1797398658478505984 |
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| author | G. Sathiyaraj A. Vignesh K. Priyanka K.S. Neethu D. Badhmapriya K. Preethi N. Dharmaraj M.V. Kaveri |
| author_facet | G. Sathiyaraj A. Vignesh K. Priyanka K.S. Neethu D. Badhmapriya K. Preethi N. Dharmaraj M.V. Kaveri |
| author_sort | G. Sathiyaraj |
| collection | DOAJ |
| description | This work describes the fabrication of a carbazole derivative 1 namely (E)-5-(diethylamino)-2-((9-ethyl-9H-carbazol-3-yl)imino)methyl)phenol(1) based colorimetric probe for the selective detection of copper (II) ions. The as-prepared carbazole derivative was characterized using various spectral techniques including UV–visible absorption, Emission, FT-IR, 1H NMR, 13C NMR and mass spectra. The colorimetric chemosensing potential of the synthesized carbazole derivative 1 to detect Cu2+ ions in a solution of different cations at different emission wavelengths based on photo-induced electron transfer (PET) mechanism was undertaken. In addition, the probe 1 showed significant DPPH scavenging activity. Antimicrobial and anti-inflammatory activities of the carbazole derivative 1 were also assessed. The selectivity of probe 1 towards Cu2+ ions could be exploited to reduce copper induced toxicity. |
| first_indexed | 2024-03-09T01:28:45Z |
| format | Article |
| id | doaj.art-da0fb0d754f14b45bd2c35a52dd5859e |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-09T01:28:45Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-da0fb0d754f14b45bd2c35a52dd5859e2023-12-10T06:15:23ZengElsevierResults in Chemistry2211-71562023-12-016101141Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activityG. Sathiyaraj0A. Vignesh1K. Priyanka2K.S. Neethu3D. Badhmapriya4K. Preethi5N. Dharmaraj6M.V. Kaveri7Department of Chemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, IndiaDepartment of Botany, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India; Department of Botany, Nallamuthu Gounder Mahalingam College (Autonomous), Bharathiar University (Affiliated), Pollachi- 642 001, Tamil Nadu, IndiaDepartment of Microbial Biotechnology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, IndiaDepartment of Chemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India; Bharathiar Cancer Theranostics Research Centre, Bharathiar University, Coimbatore 641 046, Tamil Nadu, IndiaDepartment of Chemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, IndiaDepartment of Microbial Biotechnology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, IndiaDepartment of Chemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, IndiaDepartment of Chemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India; Corresponding author.This work describes the fabrication of a carbazole derivative 1 namely (E)-5-(diethylamino)-2-((9-ethyl-9H-carbazol-3-yl)imino)methyl)phenol(1) based colorimetric probe for the selective detection of copper (II) ions. The as-prepared carbazole derivative was characterized using various spectral techniques including UV–visible absorption, Emission, FT-IR, 1H NMR, 13C NMR and mass spectra. The colorimetric chemosensing potential of the synthesized carbazole derivative 1 to detect Cu2+ ions in a solution of different cations at different emission wavelengths based on photo-induced electron transfer (PET) mechanism was undertaken. In addition, the probe 1 showed significant DPPH scavenging activity. Antimicrobial and anti-inflammatory activities of the carbazole derivative 1 were also assessed. The selectivity of probe 1 towards Cu2+ ions could be exploited to reduce copper induced toxicity.http://www.sciencedirect.com/science/article/pii/S2211715623003806Carbazole based metal sensorNaked eye detection of copper ionsPhoto electron transferOxidative stress reductionInflammation healingMicrobes inhibition |
| spellingShingle | G. Sathiyaraj A. Vignesh K. Priyanka K.S. Neethu D. Badhmapriya K. Preethi N. Dharmaraj M.V. Kaveri Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity Results in Chemistry Carbazole based metal sensor Naked eye detection of copper ions Photo electron transfer Oxidative stress reduction Inflammation healing Microbes inhibition |
| title | Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity |
| title_full | Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity |
| title_fullStr | Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity |
| title_full_unstemmed | Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity |
| title_short | Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity |
| title_sort | construction of 3 amino 9 ethylcarbazole scaffold for multifunctional applications chemosensor for copper ii ions along with antibacterial antioxidant and anti inflammatory activity |
| topic | Carbazole based metal sensor Naked eye detection of copper ions Photo electron transfer Oxidative stress reduction Inflammation healing Microbes inhibition |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623003806 |
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