The impact of cyclophosphamide versus high-level of ionizing radiation on the immune response
The immune response to various high doses of Ionizing Radiation (IR) is investigated in this study compared to the non-irradiated group and other immunosuppressive conditions. Thirty rats were divided into six different groups. Group I received no radiation or medications. Groups II, III, IV, and V...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023052337 |
| _version_ | 1797771460028137472 |
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| author | Soha M. Hussien |
| author_facet | Soha M. Hussien |
| author_sort | Soha M. Hussien |
| collection | DOAJ |
| description | The immune response to various high doses of Ionizing Radiation (IR) is investigated in this study compared to the non-irradiated group and other immunosuppressive conditions. Thirty rats were divided into six different groups. Group I received no radiation or medications. Groups II, III, IV, and V were subjected to the entire body to 1, 2, 3, and 5 Gray (Gy) of IR. Cyclophosphamide 50 mg/kg was administered intraperitoneally to Group VI. Serum levels of Interleukin-2/1-beta, Tumor Necrosis Factor-alpha (TNF-α), and Interferon-gamma (INF-γ) were measured one day after irradiation. The immunosuppressive effect of cyclophosphamide reduced the majority of the evaluated parameters. When high doses of IR, notably greater than 1Gy, were investigated, all measured parameters increased consistently. Finally, high doses of IR amplify essential pro-inflammatory responses and cannot be used to suppress the immune system in a single dose. More research is needed to clarify immune responses and their therapeutic potential in response to high or low IR doses. |
| first_indexed | 2024-03-12T21:37:53Z |
| format | Article |
| id | doaj.art-da0fe5b4ae774e69b95525c2a21fe026 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T21:37:53Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-da0fe5b4ae774e69b95525c2a21fe0262023-07-27T05:58:17ZengElsevierHeliyon2405-84402023-07-0197e18025The impact of cyclophosphamide versus high-level of ionizing radiation on the immune responseSoha M. Hussien0Radiation Safety Department, Nuclear and Radiological Safety Research Center, Egyptian Atomic Energy Authority, EgyptThe immune response to various high doses of Ionizing Radiation (IR) is investigated in this study compared to the non-irradiated group and other immunosuppressive conditions. Thirty rats were divided into six different groups. Group I received no radiation or medications. Groups II, III, IV, and V were subjected to the entire body to 1, 2, 3, and 5 Gray (Gy) of IR. Cyclophosphamide 50 mg/kg was administered intraperitoneally to Group VI. Serum levels of Interleukin-2/1-beta, Tumor Necrosis Factor-alpha (TNF-α), and Interferon-gamma (INF-γ) were measured one day after irradiation. The immunosuppressive effect of cyclophosphamide reduced the majority of the evaluated parameters. When high doses of IR, notably greater than 1Gy, were investigated, all measured parameters increased consistently. Finally, high doses of IR amplify essential pro-inflammatory responses and cannot be used to suppress the immune system in a single dose. More research is needed to clarify immune responses and their therapeutic potential in response to high or low IR doses.http://www.sciencedirect.com/science/article/pii/S2405844023052337CytokineIonizing radiationImmunological conditionsImmune suppressionGamma radiationCyclophosphamide |
| spellingShingle | Soha M. Hussien The impact of cyclophosphamide versus high-level of ionizing radiation on the immune response Heliyon Cytokine Ionizing radiation Immunological conditions Immune suppression Gamma radiation Cyclophosphamide |
| title | The impact of cyclophosphamide versus high-level of ionizing radiation on the immune response |
| title_full | The impact of cyclophosphamide versus high-level of ionizing radiation on the immune response |
| title_fullStr | The impact of cyclophosphamide versus high-level of ionizing radiation on the immune response |
| title_full_unstemmed | The impact of cyclophosphamide versus high-level of ionizing radiation on the immune response |
| title_short | The impact of cyclophosphamide versus high-level of ionizing radiation on the immune response |
| title_sort | impact of cyclophosphamide versus high level of ionizing radiation on the immune response |
| topic | Cytokine Ionizing radiation Immunological conditions Immune suppression Gamma radiation Cyclophosphamide |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023052337 |
| work_keys_str_mv | AT sohamhussien theimpactofcyclophosphamideversushighlevelofionizingradiationontheimmuneresponse AT sohamhussien impactofcyclophosphamideversushighlevelofionizingradiationontheimmuneresponse |