Primary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transfer
Myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G-associated optic neuritis (ON) is a newly recognized antibody-mediated demyelinating disease of the central nervous system, resulting in acute visual loss and pain with eye movement. The effects of pregnancy on disease pathogenesis remain in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=2;spage=203;epage=205;aulast=Siegel |
| _version_ | 1818676987526381568 |
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| author | Dana Rebecca Siegel Thanh-Ha Luu Malgorzata E Skaznik-Wikiel |
| author_facet | Dana Rebecca Siegel Thanh-Ha Luu Malgorzata E Skaznik-Wikiel |
| author_sort | Dana Rebecca Siegel |
| collection | DOAJ |
| description | Myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G-associated optic neuritis (ON) is a newly recognized antibody-mediated demyelinating disease of the central nervous system, resulting in acute visual loss and pain with eye movement. The effects of pregnancy on disease pathogenesis remain incompletely understood. Herein, we present a novel association between a frozen embryo transfer (FET) and the first manifestation of MOG-ON in a previously healthy patient with unexplained infertility. The patient presented with acute bilateral visual loss 3 weeks after a single FET and was found to test positive for MOG antibodies with an otherwise unremarkable workup. The patient's vision returned to baseline with high-dose intravenous methylprednisolone and therapeutic plasma exchange. This is the first published case highlighting an association between MOG-ON and assisted reproductive technology (ART) in a patient without prior risk factors. Further studies are needed to clarify the effects of ART and pregnancy in general on disease pathogenesis. |
| first_indexed | 2024-12-17T08:52:12Z |
| format | Article |
| id | doaj.art-da102c792b314714984e61a6d28f54b0 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-17T08:52:12Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-da102c792b314714984e61a6d28f54b02022-12-21T21:56:03ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662021-01-0114220320510.4103/jhrs.jhrs_30_21Primary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transferDana Rebecca SiegelThanh-Ha LuuMalgorzata E Skaznik-WikielMyelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G-associated optic neuritis (ON) is a newly recognized antibody-mediated demyelinating disease of the central nervous system, resulting in acute visual loss and pain with eye movement. The effects of pregnancy on disease pathogenesis remain incompletely understood. Herein, we present a novel association between a frozen embryo transfer (FET) and the first manifestation of MOG-ON in a previously healthy patient with unexplained infertility. The patient presented with acute bilateral visual loss 3 weeks after a single FET and was found to test positive for MOG antibodies with an otherwise unremarkable workup. The patient's vision returned to baseline with high-dose intravenous methylprednisolone and therapeutic plasma exchange. This is the first published case highlighting an association between MOG-ON and assisted reproductive technology (ART) in a patient without prior risk factors. Further studies are needed to clarify the effects of ART and pregnancy in general on disease pathogenesis.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=2;spage=203;epage=205;aulast=Siegelassisted reproductive technologyautoimmune diseasescase reportmyelin oligodendrocyte glycoproteinoptic neuritis |
| spellingShingle | Dana Rebecca Siegel Thanh-Ha Luu Malgorzata E Skaznik-Wikiel Primary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transfer Journal of Human Reproductive Sciences assisted reproductive technology autoimmune diseases case report myelin oligodendrocyte glycoprotein optic neuritis |
| title | Primary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transfer |
| title_full | Primary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transfer |
| title_fullStr | Primary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transfer |
| title_full_unstemmed | Primary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transfer |
| title_short | Primary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transfer |
| title_sort | primary myelin oligodendrocyte glycoprotein immunoglobulin g associated optic neuritis presenting after a frozen embryo transfer |
| topic | assisted reproductive technology autoimmune diseases case report myelin oligodendrocyte glycoprotein optic neuritis |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=2;spage=203;epage=205;aulast=Siegel |
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