Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer.
Dysregulated miRNAs play critical roles during carcinogenesis and cancer progression. In the present study, the function of miR-1228* in regulating cancer progression was investigated in gastric cancer. Decreased expression of miR-1228* was observed in human gastric cancer tissues comparing to norma...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3595239?pdf=render |
| _version_ | 1819062084815552512 |
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| author | Litao Jia Jia Wu Lu Zhang Jiamin Chen Dandan Zhong Song Xu Chuangao Xie Jianting Cai |
| author_facet | Litao Jia Jia Wu Lu Zhang Jiamin Chen Dandan Zhong Song Xu Chuangao Xie Jianting Cai |
| author_sort | Litao Jia |
| collection | DOAJ |
| description | Dysregulated miRNAs play critical roles during carcinogenesis and cancer progression. In the present study, the function of miR-1228* in regulating cancer progression was investigated in gastric cancer. Decreased expression of miR-1228* was observed in human gastric cancer tissues comparing to normal tissues. Subsequently, the role of miR-1228* was evaluated in vivo using the tumor xenograft model. In this model, miR-1228* overexpression suppressed xenograft tumor formation. Furthermore, we demonstrated miR-1228* negatively regulated NF-κB activity in SGC-7901 gastric cancer cells and found that CK2A2 was a target of miR-1228*. Upregulation of miR-1228* decreased the expression of mesenchymal markers and increased the epithelial marker E-cadherin, suggesting its potential role in suppressing epithelial-mesenchymal transition. Collectively, these findings provide the first evidence that miR-1228* plays an important role in regulating gastric cancer growth and suggest that selective restoration of miR-1228* might be beneficial for gastric cancer therapy. |
| first_indexed | 2024-12-21T14:53:10Z |
| format | Article |
| id | doaj.art-da10f987cbdd4ef4a9f388602731aa54 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T14:53:10Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-da10f987cbdd4ef4a9f388602731aa542022-12-21T18:59:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5863710.1371/journal.pone.0058637Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer.Litao JiaJia WuLu ZhangJiamin ChenDandan ZhongSong XuChuangao XieJianting CaiDysregulated miRNAs play critical roles during carcinogenesis and cancer progression. In the present study, the function of miR-1228* in regulating cancer progression was investigated in gastric cancer. Decreased expression of miR-1228* was observed in human gastric cancer tissues comparing to normal tissues. Subsequently, the role of miR-1228* was evaluated in vivo using the tumor xenograft model. In this model, miR-1228* overexpression suppressed xenograft tumor formation. Furthermore, we demonstrated miR-1228* negatively regulated NF-κB activity in SGC-7901 gastric cancer cells and found that CK2A2 was a target of miR-1228*. Upregulation of miR-1228* decreased the expression of mesenchymal markers and increased the epithelial marker E-cadherin, suggesting its potential role in suppressing epithelial-mesenchymal transition. Collectively, these findings provide the first evidence that miR-1228* plays an important role in regulating gastric cancer growth and suggest that selective restoration of miR-1228* might be beneficial for gastric cancer therapy.http://europepmc.org/articles/PMC3595239?pdf=render |
| spellingShingle | Litao Jia Jia Wu Lu Zhang Jiamin Chen Dandan Zhong Song Xu Chuangao Xie Jianting Cai Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. PLoS ONE |
| title | Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. |
| title_full | Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. |
| title_fullStr | Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. |
| title_full_unstemmed | Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. |
| title_short | Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. |
| title_sort | restoration of mir 1228 expression suppresses epithelial mesenchymal transition in gastric cancer |
| url | http://europepmc.org/articles/PMC3595239?pdf=render |
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