Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The disease has a cell-mediated immune reaction which is precipitated by a specific trigger which turns the self-peptides antigenic. The role of human papillomavirus (HPV) in the malignant transformation of oral LP (OLP) has always...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=5;spage=62;epage=67;aulast=Vijayan |
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| author | Aswathy K Vijayan Arvind Muthukrishnan Mathew Vidyadharan Aparna M Nair |
| author_facet | Aswathy K Vijayan Arvind Muthukrishnan Mathew Vidyadharan Aparna M Nair |
| author_sort | Aswathy K Vijayan |
| collection | DOAJ |
| description | Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The disease has a cell-mediated immune reaction which is precipitated by a specific trigger which turns the self-peptides antigenic. The role of human papillomavirus (HPV) in the malignant transformation of oral LP (OLP) has always been debated. Establishing a definitive part played by HPV in the malignant transformation of OLP, would possibly provide screening for the viruses, HPV vaccination, and antiviral therapy along with conventional treatment in LP which could improve prognosis. This systematic review is to assess the role of HPV in the malignant transformation of OLP. We performed a systematic search of PubMed, MEDLINE, and Google. The information was extracted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All full-text papers that assessed the association of HPV in malignant transformation of OLP were considered eligible. The outcome parameter included the malignant transformation of OLP. We found a total of 19 studies from which five were found suitable for the review. Results from this systematic review showed HPV is associated with OLP. There is an increased prevalence of HPV in the erosive-atrophic (EA) variant of OLP compared to non-EA variant. There seems to be no strong evidence to prove the association between HPV and malignant transformation of OLP. Taking up the oncogenic potential of high-risk types and OLP as a potentially malignant disorder, more number of studies need to be performed on the dysplastic subtype of OLP and in those OLP lesions that progress to oral squamous cell carcinomas. |
| first_indexed | 2024-12-17T00:17:35Z |
| format | Article |
| id | doaj.art-da1119456b254fc3a6bcbf24928abe4d |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-12-17T00:17:35Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-da1119456b254fc3a6bcbf24928abe4d2022-12-21T22:10:39ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062021-01-01135626710.4103/jpbs.JPBS_836_20Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic reviewAswathy K VijayanArvind MuthukrishnanMathew VidyadharanAparna M NairLichen planus (LP) is a chronic inflammatory mucocutaneous disease. The disease has a cell-mediated immune reaction which is precipitated by a specific trigger which turns the self-peptides antigenic. The role of human papillomavirus (HPV) in the malignant transformation of oral LP (OLP) has always been debated. Establishing a definitive part played by HPV in the malignant transformation of OLP, would possibly provide screening for the viruses, HPV vaccination, and antiviral therapy along with conventional treatment in LP which could improve prognosis. This systematic review is to assess the role of HPV in the malignant transformation of OLP. We performed a systematic search of PubMed, MEDLINE, and Google. The information was extracted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All full-text papers that assessed the association of HPV in malignant transformation of OLP were considered eligible. The outcome parameter included the malignant transformation of OLP. We found a total of 19 studies from which five were found suitable for the review. Results from this systematic review showed HPV is associated with OLP. There is an increased prevalence of HPV in the erosive-atrophic (EA) variant of OLP compared to non-EA variant. There seems to be no strong evidence to prove the association between HPV and malignant transformation of OLP. Taking up the oncogenic potential of high-risk types and OLP as a potentially malignant disorder, more number of studies need to be performed on the dysplastic subtype of OLP and in those OLP lesions that progress to oral squamous cell carcinomas.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=5;spage=62;epage=67;aulast=Vijayandysplasiahuman papillomavirusmalignant transformationoral lichen planus |
| spellingShingle | Aswathy K Vijayan Arvind Muthukrishnan Mathew Vidyadharan Aparna M Nair Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review Journal of Pharmacy and Bioallied Sciences dysplasia human papillomavirus malignant transformation oral lichen planus |
| title | Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review |
| title_full | Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review |
| title_fullStr | Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review |
| title_full_unstemmed | Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review |
| title_short | Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review |
| title_sort | role of human papilloma virus in malignant transformation of oral lichen planus a systematic review |
| topic | dysplasia human papillomavirus malignant transformation oral lichen planus |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=5;spage=62;epage=67;aulast=Vijayan |
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