The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology
Di(2-ethylhexyl) phthalate (DEHP) is a chemical widely distributed in the environment as is extensively used in the plastic industry. DEHP is considered an endocrine disruptor chemical (EDC) and humans are inevitably and unintentionally exposed to this EDC through several sources including food, bev...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020321838 |
| _version_ | 1818665644402409472 |
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| author | Luis Daniel Martínez-Razo Alejandra Martínez-Ibarra Edgar Ricardo Vázquez-Martínez Marco Cerbón |
| author_facet | Luis Daniel Martínez-Razo Alejandra Martínez-Ibarra Edgar Ricardo Vázquez-Martínez Marco Cerbón |
| author_sort | Luis Daniel Martínez-Razo |
| collection | DOAJ |
| description | Di(2-ethylhexyl) phthalate (DEHP) is a chemical widely distributed in the environment as is extensively used in the plastic industry. DEHP is considered an endocrine disruptor chemical (EDC) and humans are inevitably and unintentionally exposed to this EDC through several sources including food, beverages, cosmetics, medical devices, among others. DEHP exposure has been associated and may be involved in the development of various pathologies; importantly, pregnant women are a particular risk group considering that endocrine alterations during gestation may impact fetal programming leading to the development of several chronic diseases in adulthood. Recent studies have indicated that exposure to DEHP and its metabolite Mono(2-ethylhexyl) phthalate (MEHP) may impair placental development and function, which in turn would have a negative impact on fetal growth.Studies performed in several trophoblastic and placental models have shown the negative impact of DEHP and MEHP in key processes related to placental development such as implantation, differentiation, invasion and angiogenesis. In addition, many alterations in placental functions like hormone signaling, metabolism, transfer of nutrients, immunomodulation and oxidative stress response have been reported. Moreover, clinical-epidemiological evidence supports the association between DEHP exposure and adverse pregnancy outcomes and pathologies. In this review, we aim to summarize for the first time current knowledge about the impact of DEHP and MEHP exposure on placental development and pathophysiology, as well as the mechanisms involved. We also remark the importance of exploring DEHP and MEHP effects in different trophoblast cell populations and discuss new perspectives regarding this topic. |
| first_indexed | 2024-12-17T05:51:55Z |
| format | Article |
| id | doaj.art-da14e939d7184a43999555ca6f112689 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-17T05:51:55Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-da14e939d7184a43999555ca6f1126892022-12-21T22:01:08ZengElsevierEnvironment International0160-41202021-01-01146106228The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiologyLuis Daniel Martínez-Razo0Alejandra Martínez-Ibarra1Edgar Ricardo Vázquez-Martínez2Marco Cerbón3Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes” – Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 11000, MexicoUnidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes” – Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 11000, Mexico; Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Ciudad de México 04960, MexicoUnidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes” – Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 11000, MexicoUnidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes” – Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 11000, Mexico; Corresponding author.Di(2-ethylhexyl) phthalate (DEHP) is a chemical widely distributed in the environment as is extensively used in the plastic industry. DEHP is considered an endocrine disruptor chemical (EDC) and humans are inevitably and unintentionally exposed to this EDC through several sources including food, beverages, cosmetics, medical devices, among others. DEHP exposure has been associated and may be involved in the development of various pathologies; importantly, pregnant women are a particular risk group considering that endocrine alterations during gestation may impact fetal programming leading to the development of several chronic diseases in adulthood. Recent studies have indicated that exposure to DEHP and its metabolite Mono(2-ethylhexyl) phthalate (MEHP) may impair placental development and function, which in turn would have a negative impact on fetal growth.Studies performed in several trophoblastic and placental models have shown the negative impact of DEHP and MEHP in key processes related to placental development such as implantation, differentiation, invasion and angiogenesis. In addition, many alterations in placental functions like hormone signaling, metabolism, transfer of nutrients, immunomodulation and oxidative stress response have been reported. Moreover, clinical-epidemiological evidence supports the association between DEHP exposure and adverse pregnancy outcomes and pathologies. In this review, we aim to summarize for the first time current knowledge about the impact of DEHP and MEHP exposure on placental development and pathophysiology, as well as the mechanisms involved. We also remark the importance of exploring DEHP and MEHP effects in different trophoblast cell populations and discuss new perspectives regarding this topic.http://www.sciencedirect.com/science/article/pii/S0160412020321838Di-(2-ethylhexyl) phthalateMono(2-ethylhexyl) phthalatePlacentaTrophoblastDevelopmentPregnancy disorder |
| spellingShingle | Luis Daniel Martínez-Razo Alejandra Martínez-Ibarra Edgar Ricardo Vázquez-Martínez Marco Cerbón The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology Environment International Di-(2-ethylhexyl) phthalate Mono(2-ethylhexyl) phthalate Placenta Trophoblast Development Pregnancy disorder |
| title | The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology |
| title_full | The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology |
| title_fullStr | The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology |
| title_full_unstemmed | The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology |
| title_short | The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology |
| title_sort | impact of di 2 ethylhexyl phthalate and mono 2 ethylhexyl phthalate in placental development function and pathophysiology |
| topic | Di-(2-ethylhexyl) phthalate Mono(2-ethylhexyl) phthalate Placenta Trophoblast Development Pregnancy disorder |
| url | http://www.sciencedirect.com/science/article/pii/S0160412020321838 |
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