Circular RNAs as biomarkers for lung cancer
Lung cancer is the leading cause of death and morbidity from malignant neoplasms worldwide, and its poor prognosis places a heavy burden on patients. A large percentage of lung cancer cases are associated with smoking. A significant number of non-smokers also develop the disease, suggesting an epige...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-03-01
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| Series: | Non-coding RNA Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054022000683 |
| _version_ | 1811178280609382400 |
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| author | Albert Sufianov Sema Begliarzade Aferin Beilerli Yanchao Liang Tatiana Ilyasova Ozal Beylerli |
| author_facet | Albert Sufianov Sema Begliarzade Aferin Beilerli Yanchao Liang Tatiana Ilyasova Ozal Beylerli |
| author_sort | Albert Sufianov |
| collection | DOAJ |
| description | Lung cancer is the leading cause of death and morbidity from malignant neoplasms worldwide, and its poor prognosis places a heavy burden on patients. A large percentage of lung cancer cases are associated with smoking. A significant number of non-smokers also develop the disease, suggesting an epigenetic and genetic mechanism for the development of lung cancer. The current situation with the diagnosis and treatment of lung cancer remains grim, and effective therapeutic targets and molecular markers are urgently needed. Circular RNAs (circRNAs) are covalently closed non-coding RNAs that have received much attention due to their biological properties such as conservatism, stability, and tissue specificity. Many studies have shown that circRNAs are involved in the regulation of lung cancer through various mechanisms, such as microRNA adsorption, and play an important role in the early diagnosis, treatment, and prognosis of lung cancer. In recent years, it has become increasingly clear that circRNAs are involved in the proliferation, migration, and invasion of lung cancer cells. Differentially expressed circRNAs can be used as non-invasive diagnostic and prognostic markers of lung cancer. This article summarizes the current advances of circRNAs in the diagnosis, treatment and prognosis of lung cancer. |
| first_indexed | 2024-04-11T06:15:44Z |
| format | Article |
| id | doaj.art-da15a130c1064bcb8a7301ad1c9c8992 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-11T06:15:44Z |
| publishDate | 2023-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-da15a130c1064bcb8a7301ad1c9c89922022-12-22T04:41:03ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402023-03-01818388Circular RNAs as biomarkers for lung cancerAlbert Sufianov0Sema Begliarzade1Aferin Beilerli2Yanchao Liang3Tatiana Ilyasova4Ozal Beylerli5Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaRepublican Clinical Perinatal Center, Ufa, Republic of Bashkortostan, 450106, RussiaDepartment of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, RussiaDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, ChinaDepartment of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, RussiaEducational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Corresponding author. Рeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation.Lung cancer is the leading cause of death and morbidity from malignant neoplasms worldwide, and its poor prognosis places a heavy burden on patients. A large percentage of lung cancer cases are associated with smoking. A significant number of non-smokers also develop the disease, suggesting an epigenetic and genetic mechanism for the development of lung cancer. The current situation with the diagnosis and treatment of lung cancer remains grim, and effective therapeutic targets and molecular markers are urgently needed. Circular RNAs (circRNAs) are covalently closed non-coding RNAs that have received much attention due to their biological properties such as conservatism, stability, and tissue specificity. Many studies have shown that circRNAs are involved in the regulation of lung cancer through various mechanisms, such as microRNA adsorption, and play an important role in the early diagnosis, treatment, and prognosis of lung cancer. In recent years, it has become increasingly clear that circRNAs are involved in the proliferation, migration, and invasion of lung cancer cells. Differentially expressed circRNAs can be used as non-invasive diagnostic and prognostic markers of lung cancer. This article summarizes the current advances of circRNAs in the diagnosis, treatment and prognosis of lung cancer.http://www.sciencedirect.com/science/article/pii/S2468054022000683Noncoding RNAsCircular RNAsLung cancerBiology functionBiomarker |
| spellingShingle | Albert Sufianov Sema Begliarzade Aferin Beilerli Yanchao Liang Tatiana Ilyasova Ozal Beylerli Circular RNAs as biomarkers for lung cancer Non-coding RNA Research Noncoding RNAs Circular RNAs Lung cancer Biology function Biomarker |
| title | Circular RNAs as biomarkers for lung cancer |
| title_full | Circular RNAs as biomarkers for lung cancer |
| title_fullStr | Circular RNAs as biomarkers for lung cancer |
| title_full_unstemmed | Circular RNAs as biomarkers for lung cancer |
| title_short | Circular RNAs as biomarkers for lung cancer |
| title_sort | circular rnas as biomarkers for lung cancer |
| topic | Noncoding RNAs Circular RNAs Lung cancer Biology function Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2468054022000683 |
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