Natural Cyanobacterial Polymer-Based Coating as a Preventive Strategy to Avoid Catheter-Associated Urinary Tract Infections
Catheter-associated urinary tract infections (CAUTIs) represent about 40% of all healthcare-associated infections. Herein, the authors report the further development of an infection preventive anti-adhesive coating (CyanoCoating) meant for urinary catheters, and based on a natural polymer released b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/6/279 |
| _version_ | 1827716265998811136 |
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| author | Bruna Costa Rita Mota Paula Tamagnini M. Cristina L. Martins Fabíola Costa |
| author_facet | Bruna Costa Rita Mota Paula Tamagnini M. Cristina L. Martins Fabíola Costa |
| author_sort | Bruna Costa |
| collection | DOAJ |
| description | Catheter-associated urinary tract infections (CAUTIs) represent about 40% of all healthcare-associated infections. Herein, the authors report the further development of an infection preventive anti-adhesive coating (CyanoCoating) meant for urinary catheters, and based on a natural polymer released by a marine cyanobacterium. CyanoCoating performance was assessed against relevant CAUTI etiological agents, namely <i>Escherichia coli</i>, <i>Proteus mirabilis</i>, <i>Klebsiella pneumoniae,</i> methicillin resistant <i>Staphylococcus aureus</i> (MRSA), and <i>Candida albicans</i> in the presence of culture medium or artificial urine, and under biofilm promoting settings. CyanoCoating displayed a broad anti-adhesive efficiency against all the uropathogens tested (68–95%), even in the presence of artificial urine (58–100%) with exception of <i>P. mirabilis</i> in the latter condition. Under biofilm-promoting settings, CyanoCoating reduced biofilm formation by <i>E. coli</i>, <i>P. mirabilis,</i> and <i>C. albicans</i> (30–60%). In addition, CyanoCoating prevented large crystals encrustation, and its sterilization with ethylene oxide did not impact the coating stability. Therefore, CyanoCoating constitutes a step forward for the implementation of antibiotic-free alternative strategies to fight CAUTIs. |
| first_indexed | 2024-03-10T19:36:05Z |
| format | Article |
| id | doaj.art-da161bbc4f494a7b8939aa71137d931b |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T19:36:05Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-da161bbc4f494a7b8939aa71137d931b2023-11-20T01:43:51ZengMDPI AGMarine Drugs1660-33972020-05-0118627910.3390/md18060279Natural Cyanobacterial Polymer-Based Coating as a Preventive Strategy to Avoid Catheter-Associated Urinary Tract InfectionsBruna Costa0Rita Mota1Paula Tamagnini2M. Cristina L. Martins3Fabíola Costa4i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugali3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugali3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugali3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugali3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, PortugalCatheter-associated urinary tract infections (CAUTIs) represent about 40% of all healthcare-associated infections. Herein, the authors report the further development of an infection preventive anti-adhesive coating (CyanoCoating) meant for urinary catheters, and based on a natural polymer released by a marine cyanobacterium. CyanoCoating performance was assessed against relevant CAUTI etiological agents, namely <i>Escherichia coli</i>, <i>Proteus mirabilis</i>, <i>Klebsiella pneumoniae,</i> methicillin resistant <i>Staphylococcus aureus</i> (MRSA), and <i>Candida albicans</i> in the presence of culture medium or artificial urine, and under biofilm promoting settings. CyanoCoating displayed a broad anti-adhesive efficiency against all the uropathogens tested (68–95%), even in the presence of artificial urine (58–100%) with exception of <i>P. mirabilis</i> in the latter condition. Under biofilm-promoting settings, CyanoCoating reduced biofilm formation by <i>E. coli</i>, <i>P. mirabilis,</i> and <i>C. albicans</i> (30–60%). In addition, CyanoCoating prevented large crystals encrustation, and its sterilization with ethylene oxide did not impact the coating stability. Therefore, CyanoCoating constitutes a step forward for the implementation of antibiotic-free alternative strategies to fight CAUTIs.https://www.mdpi.com/1660-3397/18/6/279cyanobacteriauropathogensanti-adhesive coatingurinary catheterssurface modificationcatheter-associated urinary tract infections |
| spellingShingle | Bruna Costa Rita Mota Paula Tamagnini M. Cristina L. Martins Fabíola Costa Natural Cyanobacterial Polymer-Based Coating as a Preventive Strategy to Avoid Catheter-Associated Urinary Tract Infections Marine Drugs cyanobacteria uropathogens anti-adhesive coating urinary catheters surface modification catheter-associated urinary tract infections |
| title | Natural Cyanobacterial Polymer-Based Coating as a Preventive Strategy to Avoid Catheter-Associated Urinary Tract Infections |
| title_full | Natural Cyanobacterial Polymer-Based Coating as a Preventive Strategy to Avoid Catheter-Associated Urinary Tract Infections |
| title_fullStr | Natural Cyanobacterial Polymer-Based Coating as a Preventive Strategy to Avoid Catheter-Associated Urinary Tract Infections |
| title_full_unstemmed | Natural Cyanobacterial Polymer-Based Coating as a Preventive Strategy to Avoid Catheter-Associated Urinary Tract Infections |
| title_short | Natural Cyanobacterial Polymer-Based Coating as a Preventive Strategy to Avoid Catheter-Associated Urinary Tract Infections |
| title_sort | natural cyanobacterial polymer based coating as a preventive strategy to avoid catheter associated urinary tract infections |
| topic | cyanobacteria uropathogens anti-adhesive coating urinary catheters surface modification catheter-associated urinary tract infections |
| url | https://www.mdpi.com/1660-3397/18/6/279 |
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