Advances of mRNA vaccine in tumor: a maze of opportunities and challenges
Abstract High-frequency mutations in tumor genomes could be exploited as an asset for developing tumor vaccines. In recent years, with the tremendous breakthrough in genomics, intelligence algorithm, and in-depth insight of tumor immunology, it has become possible to rapidly target genomic alteratio...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-01-01
|
| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-023-00449-w |
| _version_ | 1797945839379808256 |
|---|---|
| author | Yuan Yuan Fan Gao Ying Chang Qiu Zhao Xingxing He |
| author_facet | Yuan Yuan Fan Gao Ying Chang Qiu Zhao Xingxing He |
| author_sort | Yuan Yuan |
| collection | DOAJ |
| description | Abstract High-frequency mutations in tumor genomes could be exploited as an asset for developing tumor vaccines. In recent years, with the tremendous breakthrough in genomics, intelligence algorithm, and in-depth insight of tumor immunology, it has become possible to rapidly target genomic alterations in tumor cell and rationally select vaccine targets. Among a variety of candidate vaccine platforms, the early application of mRNA was limited by instability low efficiency and excessive immunogenicity until the successful development of mRNA vaccines against SARS-COV-2 broken of technical bottleneck in vaccine preparation, allowing tumor mRNA vaccines to be prepared rapidly in an economical way with good performance of stability and efficiency. In this review, we systematically summarized the classification and characteristics of tumor antigens, the general process and methods for screening neoantigens, the strategies of vaccine preparations and advances in clinical trials, as well as presented the main challenges in the current mRNA tumor vaccine development. |
| first_indexed | 2024-04-10T21:01:27Z |
| format | Article |
| id | doaj.art-da178c95e3bd448f86188b2373116019 |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-04-10T21:01:27Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-da178c95e3bd448f86188b23731160192023-01-22T12:20:31ZengBMCBiomarker Research2050-77712023-01-0111112510.1186/s40364-023-00449-wAdvances of mRNA vaccine in tumor: a maze of opportunities and challengesYuan Yuan0Fan Gao1Ying Chang2Qiu Zhao3Xingxing He4Department of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityAbstract High-frequency mutations in tumor genomes could be exploited as an asset for developing tumor vaccines. In recent years, with the tremendous breakthrough in genomics, intelligence algorithm, and in-depth insight of tumor immunology, it has become possible to rapidly target genomic alterations in tumor cell and rationally select vaccine targets. Among a variety of candidate vaccine platforms, the early application of mRNA was limited by instability low efficiency and excessive immunogenicity until the successful development of mRNA vaccines against SARS-COV-2 broken of technical bottleneck in vaccine preparation, allowing tumor mRNA vaccines to be prepared rapidly in an economical way with good performance of stability and efficiency. In this review, we systematically summarized the classification and characteristics of tumor antigens, the general process and methods for screening neoantigens, the strategies of vaccine preparations and advances in clinical trials, as well as presented the main challenges in the current mRNA tumor vaccine development.https://doi.org/10.1186/s40364-023-00449-wmRNA vaccineTumor antigensAlgorithmic predictionSequence optimizationAdjuvantsmRNA delivery |
| spellingShingle | Yuan Yuan Fan Gao Ying Chang Qiu Zhao Xingxing He Advances of mRNA vaccine in tumor: a maze of opportunities and challenges Biomarker Research mRNA vaccine Tumor antigens Algorithmic prediction Sequence optimization Adjuvants mRNA delivery |
| title | Advances of mRNA vaccine in tumor: a maze of opportunities and challenges |
| title_full | Advances of mRNA vaccine in tumor: a maze of opportunities and challenges |
| title_fullStr | Advances of mRNA vaccine in tumor: a maze of opportunities and challenges |
| title_full_unstemmed | Advances of mRNA vaccine in tumor: a maze of opportunities and challenges |
| title_short | Advances of mRNA vaccine in tumor: a maze of opportunities and challenges |
| title_sort | advances of mrna vaccine in tumor a maze of opportunities and challenges |
| topic | mRNA vaccine Tumor antigens Algorithmic prediction Sequence optimization Adjuvants mRNA delivery |
| url | https://doi.org/10.1186/s40364-023-00449-w |
| work_keys_str_mv | AT yuanyuan advancesofmrnavaccineintumoramazeofopportunitiesandchallenges AT fangao advancesofmrnavaccineintumoramazeofopportunitiesandchallenges AT yingchang advancesofmrnavaccineintumoramazeofopportunitiesandchallenges AT qiuzhao advancesofmrnavaccineintumoramazeofopportunitiesandchallenges AT xingxinghe advancesofmrnavaccineintumoramazeofopportunitiesandchallenges |