Genetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk region
Antioxidant activity (AOA) was measured in 185 inhabitants of the town of Seversk (members of 43 families and unrelated individuals). AOA was defined on the ability of a blood plasma to reduce an output of products, reacting with thiobarbituric acid in the model system «lecithine-Fe2 +-ions». Polymo...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2002-09-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3994 |
| _version_ | 1827992105779200000 |
|---|---|
| author | A. V. Marusin V. P. Puzyryov V. B. Salyukov E. Yu. Bragina |
| author_facet | A. V. Marusin V. P. Puzyryov V. B. Salyukov E. Yu. Bragina |
| author_sort | A. V. Marusin |
| collection | DOAJ |
| description | Antioxidant activity (AOA) was measured in 185 inhabitants of the town of Seversk (members of 43 families and unrelated individuals). AOA was defined on the ability of a blood plasma to reduce an output of products, reacting with thiobarbituric acid in the model system «lecithine-Fe2 +-ions». Polymorphism of gastrointestinal glutathione peroxidase (GPX2) gene (two-allelic dinucleotide (TC)n repeat polymorphism) was investigated in 208 individuals. The presence of seasonal changes was revealed and no influences of sex and age on AOA in the considered group were shown. Approximately 50% variance in total AOA was due to the additive effects of genes. No statistical significant association between genetic variability of GPX2 and AOA variation was revealed. Estimation of GPX2 genetic variability contribution to AOA level was 2.53%. |
| first_indexed | 2024-04-10T01:15:42Z |
| format | Article |
| id | doaj.art-da17afc21e8e42849d5db21cf52bde09 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:15:42Z |
| publishDate | 2002-09-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-da17afc21e8e42849d5db21cf52bde092023-03-13T09:58:01ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842002-09-0113243010.20538/1682-0363-2002-3-24-302598Genetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk regionA. V. Marusin0V. P. Puzyryov1V. B. Salyukov2E. Yu. Bragina3Сибирский государственный медицинский университет; НИИ медицинской генетики ТНЦ СО РАМНСибирский государственный медицинский университет; НИИ медицинской генетики ТНЦ СО РАМНСибирский государственный медицинский университет; НИИ медицинской генетики ТНЦ СО РАМНСибирский государственный медицинский университет; НИИ медицинской генетики ТНЦ СО РАМНAntioxidant activity (AOA) was measured in 185 inhabitants of the town of Seversk (members of 43 families and unrelated individuals). AOA was defined on the ability of a blood plasma to reduce an output of products, reacting with thiobarbituric acid in the model system «lecithine-Fe2 +-ions». Polymorphism of gastrointestinal glutathione peroxidase (GPX2) gene (two-allelic dinucleotide (TC)n repeat polymorphism) was investigated in 208 individuals. The presence of seasonal changes was revealed and no influences of sex and age on AOA in the considered group were shown. Approximately 50% variance in total AOA was due to the additive effects of genes. No statistical significant association between genetic variability of GPX2 and AOA variation was revealed. Estimation of GPX2 genetic variability contribution to AOA level was 2.53%.https://bulletin.ssmu.ru/jour/article/view/3994антиоксидантная активностьнаследуемостьглутатионпероксидазагенетическая изменчивость |
| spellingShingle | A. V. Marusin V. P. Puzyryov V. B. Salyukov E. Yu. Bragina Genetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk region Бюллетень сибирской медицины антиоксидантная активность наследуемость глутатионпероксидаза генетическая изменчивость |
| title | Genetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk region |
| title_full | Genetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk region |
| title_fullStr | Genetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk region |
| title_full_unstemmed | Genetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk region |
| title_short | Genetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk region |
| title_sort | genetic variability antioxidant activity of blood plasma in urban population seversk of tomsk region |
| topic | антиоксидантная активность наследуемость глутатионпероксидаза генетическая изменчивость |
| url | https://bulletin.ssmu.ru/jour/article/view/3994 |
| work_keys_str_mv | AT avmarusin geneticvariabilityantioxidantactivityofbloodplasmainurbanpopulationseverskoftomskregion AT vppuzyryov geneticvariabilityantioxidantactivityofbloodplasmainurbanpopulationseverskoftomskregion AT vbsalyukov geneticvariabilityantioxidantactivityofbloodplasmainurbanpopulationseverskoftomskregion AT eyubragina geneticvariabilityantioxidantactivityofbloodplasmainurbanpopulationseverskoftomskregion |