STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling

STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling

AimsSerine/threonine/tyrosine kinase 1 (STYK1) has been previously shown to have oncogenic properties, and emerging evidence suggests that STYK1 expression correlates with epithelial-mesenchymal transition (EMT). However, the mechanism of STYK1 involvement in oncogenesis remains unknown. The present...

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Bibliographic Details
Main Authors: Yuanyang Lai, Fang Lin, Xuejiao Wang, Jiao Zhang, Jinghua Xia, Ying Sun, Miaomiao Wen, Xiaofei Li, Zhipei Zhang, Jinbo Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
STYK1(NOK)
NSCLC
metastasis
EMT
FoxO1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.621147/full

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