Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy?
Background: While metabolic health is acknowledged to affect connective tis sue structure and function, the mechanisms are unclear. Glucocorticoids are present in almost every cell type throughout the body and control key physiological processes such as energy homeostasis, stress response, inflammat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2020-02-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/9/3/EC-19-0555.xml |
| _version_ | 1818753979608203264 |
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| author | Trevor Lewis Eva Zeisig Jamie E Gaida |
| author_facet | Trevor Lewis Eva Zeisig Jamie E Gaida |
| author_sort | Trevor Lewis |
| collection | DOAJ |
| description | Background: While metabolic health is acknowledged to affect connective tis sue structure and function, the mechanisms are unclear. Glucocorticoids are present in almost every cell type throughout the body and control key physiological processes such as energy homeostasis, stress response, inflammatory and immune processes, and cardiovascular function. Glucocorticoid excess manifests as visceral adiposity, dyslipidemia, insulin resistance, and type 2 diabetes. As these metabolic states are also associated with tendinopathy and tendon rupture, it may be that glucocorticoids excess is the link between metabolic health and tendinopathy.
Objective: To synthesise current knowledge linking glucocorticoid exposure to tendon structure and function.
Methods: Narrative literature review.
Results: We provide an overview of endogenous glucocorticoid production, regulation, and signalling. Next we review the impact that oral glucocorticoid has on risk of tendon rupture and the effect that injected glucocorticoid has on resol ution of symptoms. Then we highlight the clinical and mechanistic overlap between tendinopathy and glucocorticoid excess in the areas of visceral adiposity, dyslipidemia, insulin resistance and type 2 diabetes. In these areas, we highlight the role of glucocorticoids and how these hormones might underpin the connection between metabolic health and tendon dysfunction.
Conclusions: There are several plausible pathways through which glucocorticoids might mediate the connection between metabolic health and tendinopathy. |
| first_indexed | 2024-12-18T05:15:58Z |
| format | Article |
| id | doaj.art-da19b801bbad47e59916607dda2db82a |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-18T05:15:58Z |
| publishDate | 2020-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-da19b801bbad47e59916607dda2db82a2022-12-21T21:19:46ZengBioscientificaEndocrine Connections2049-36142049-36142020-02-0193R36R46https://doi.org/10.1530/EC-19-0555Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy?Trevor Lewis0Eva Zeisig1Jamie E Gaida2Physiotherapy Department, Aintree University Hospital NHS Foundation Trust, Liverpool, UKDepartment of Surgical and Perioperative Sciences, Umeå Univerisity, Umeå, SwedenUniversity of Canberra Research Institute for Sport and Exercise (UCRISE), Canberra, Australian Capital Territory, AustraliaBackground: While metabolic health is acknowledged to affect connective tis sue structure and function, the mechanisms are unclear. Glucocorticoids are present in almost every cell type throughout the body and control key physiological processes such as energy homeostasis, stress response, inflammatory and immune processes, and cardiovascular function. Glucocorticoid excess manifests as visceral adiposity, dyslipidemia, insulin resistance, and type 2 diabetes. As these metabolic states are also associated with tendinopathy and tendon rupture, it may be that glucocorticoids excess is the link between metabolic health and tendinopathy. Objective: To synthesise current knowledge linking glucocorticoid exposure to tendon structure and function. Methods: Narrative literature review. Results: We provide an overview of endogenous glucocorticoid production, regulation, and signalling. Next we review the impact that oral glucocorticoid has on risk of tendon rupture and the effect that injected glucocorticoid has on resol ution of symptoms. Then we highlight the clinical and mechanistic overlap between tendinopathy and glucocorticoid excess in the areas of visceral adiposity, dyslipidemia, insulin resistance and type 2 diabetes. In these areas, we highlight the role of glucocorticoids and how these hormones might underpin the connection between metabolic health and tendon dysfunction. Conclusions: There are several plausible pathways through which glucocorticoids might mediate the connection between metabolic health and tendinopathy.https://ec.bioscientifica.com/view/journals/ec/9/3/EC-19-0555.xmltendinopathyglucocorticoidscortisolhypothalamic-pituitaryadrenal axismetabolic healthtype 2 diabetes mellitusvisceral adipose tissue |
| spellingShingle | Trevor Lewis Eva Zeisig Jamie E Gaida Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy? Endocrine Connections tendinopathy glucocorticoids cortisol hypothalamic-pituitaryadrenal axis metabolic health type 2 diabetes mellitus visceral adipose tissue |
| title | Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy? |
| title_full | Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy? |
| title_fullStr | Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy? |
| title_full_unstemmed | Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy? |
| title_short | Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy? |
| title_sort | does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy |
| topic | tendinopathy glucocorticoids cortisol hypothalamic-pituitaryadrenal axis metabolic health type 2 diabetes mellitus visceral adipose tissue |
| url | https://ec.bioscientifica.com/view/journals/ec/9/3/EC-19-0555.xml |
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