Therapeutic Perspectives for Inflammation and Senescence in Osteoarthritis Using Mesenchymal Stem Cells, Mesenchymal Stem Cell-Derived Extracellular Vesicles and Senolytic Agents

Therapeutic Perspectives for Inflammation and Senescence in Osteoarthritis Using Mesenchymal Stem Cells, Mesenchymal Stem Cell-Derived Extracellular Vesicles and Senolytic Agents

Osteoarthritis (OA) is the most common cause of disability worldwide among the elderly. Alarmingly, the incidence of OA in individuals less than 40 years of age is rising, likely due to the increase in obesity and post-traumatic osteoarthritis (PTOA). In recent years, due to a better understanding o...

Full description

Bibliographic Details
Main Authors: Michael G. Rizzo, Thomas M. Best, Johnny Huard, Marc Philippon, Francis Hornicek, Zhenfeng Duan, Anthony J. Griswold, Lee D. Kaplan, Joshua M. Hare, Dimitrios Kouroupis
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
osteoarthritis
mesenchymal stem/stromal cells
senolytics
cellular senescence
extracellular vesicles
senescence-associated secretory phenotype
Online Access:https://www.mdpi.com/2073-4409/12/10/1421

Similar Items

Similar Items