Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives
Non-alcoholic fatty liver disease represents an increasing cause of chronic hepatic disease in recent years. This condition usually arises in patients with multiple comorbidities, the so-called metabolic syndrome. The therapeutic options are multiple, ranging from lifestyle modifications, pharmacolo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/6/499 |
| _version_ | 1797531620605952000 |
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| author | Michele Finotti Maurizio Romano Pasquale Auricchio Michele Scopelliti Marco Brizzolari Ugo Grossi Marco Piccino Stefano Benvenuti Giovanni Morana Umberto Cillo Giacomo Zanus |
| author_facet | Michele Finotti Maurizio Romano Pasquale Auricchio Michele Scopelliti Marco Brizzolari Ugo Grossi Marco Piccino Stefano Benvenuti Giovanni Morana Umberto Cillo Giacomo Zanus |
| author_sort | Michele Finotti |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease represents an increasing cause of chronic hepatic disease in recent years. This condition usually arises in patients with multiple comorbidities, the so-called metabolic syndrome. The therapeutic options are multiple, ranging from lifestyle modifications, pharmacological options, to liver transplantation in selected cases. The choice of the most beneficial one and their interactions can be challenging. It is mandatory to stratify the patients according to the severity of their disease to tailor the available treatments. In our contribution, we review the most recent pharmacological target therapies, the role of bariatric surgery, and the impact of liver transplantation on the NAFLD outcome. |
| first_indexed | 2024-03-10T10:47:15Z |
| format | Article |
| id | doaj.art-da1a59f1efcc4758886d4ee5856a7c1e |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T10:47:15Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-da1a59f1efcc4758886d4ee5856a7c1e2023-11-21T22:33:33ZengMDPI AGJournal of Personalized Medicine2075-44262021-06-0111649910.3390/jpm11060499Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical AlternativesMichele Finotti0Maurizio Romano1Pasquale Auricchio2Michele Scopelliti3Marco Brizzolari4Ugo Grossi5Marco Piccino6Stefano Benvenuti7Giovanni Morana8Umberto Cillo9Giacomo Zanus104th Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, 31100 Padua, Italy4th Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, 31100 Padua, ItalyHepatobiliary Surgery and Liver Transplantation Unit, DISCOG, University of Padua, 35121 Padua, Italy4th Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, 31100 Padua, Italy4th Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, 31100 Padua, Italy4th Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, 31100 Padua, Italy4th Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, 31100 Padua, ItalyGastroenterology Unit (IV), Cà Foncello Regional Hospital, 31100 Treviso, ItalyDivision of Radiology, Treviso Regional Hospital, 31100 Treviso, ItalyHepatobiliary Surgery and Liver Transplantation Unit, DISCOG, University of Padua, 35121 Padua, Italy4th Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, 31100 Padua, ItalyNon-alcoholic fatty liver disease represents an increasing cause of chronic hepatic disease in recent years. This condition usually arises in patients with multiple comorbidities, the so-called metabolic syndrome. The therapeutic options are multiple, ranging from lifestyle modifications, pharmacological options, to liver transplantation in selected cases. The choice of the most beneficial one and their interactions can be challenging. It is mandatory to stratify the patients according to the severity of their disease to tailor the available treatments. In our contribution, we review the most recent pharmacological target therapies, the role of bariatric surgery, and the impact of liver transplantation on the NAFLD outcome.https://www.mdpi.com/2075-4426/11/6/499non-alcoholic fatty liver diseaseliver transplantationbariatric surgery |
| spellingShingle | Michele Finotti Maurizio Romano Pasquale Auricchio Michele Scopelliti Marco Brizzolari Ugo Grossi Marco Piccino Stefano Benvenuti Giovanni Morana Umberto Cillo Giacomo Zanus Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives Journal of Personalized Medicine non-alcoholic fatty liver disease liver transplantation bariatric surgery |
| title | Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives |
| title_full | Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives |
| title_fullStr | Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives |
| title_full_unstemmed | Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives |
| title_short | Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives |
| title_sort | target therapies for nash nafld from the molecular aspect to the pharmacological and surgical alternatives |
| topic | non-alcoholic fatty liver disease liver transplantation bariatric surgery |
| url | https://www.mdpi.com/2075-4426/11/6/499 |
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