Protective Effects of Alpha-Lipoic Acid on Cerebral Vasospasm in Rats
Objective: This study is an examination of the protective effects of alpha-lipoic acid (ALA) on cerebral vasospasm in an experimental rat model with subarachnoid hemorrhage (SAH) using biochemical, pathological, and histomorphometric analyses. Methods: A total of 28 albino Wistar rats were randoml...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2021-01-01
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| Series: | Southern Clinics of Istanbul Eurasia |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-28863 |
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| author | Hasan Ocak Evren Aydoğmus Burak Bahadır Murat Kalaycı Emrah Keski&775;n Bektaş Açıkgöz |
| author_facet | Hasan Ocak Evren Aydoğmus Burak Bahadır Murat Kalaycı Emrah Keski&775;n Bektaş Açıkgöz |
| author_sort | Hasan Ocak |
| collection | DOAJ |
| description | Objective: This study is an examination of the protective effects of alpha-lipoic acid (ALA) on cerebral vasospasm in an experimental rat model with subarachnoid hemorrhage (SAH) using biochemical, pathological, and histomorphometric analyses.
Methods: A total of 28 albino Wistar rats were randomly categorized into 4 groups (n=7 each): Group (G)1, no experimental intervention; G2, subjected to SAH; G3, subjected to SAH and given physiological saline (100 mg/kg); and G4, subjected to SAH and treated with ALA (100mg/kg).
Results: No statistically significant decrease in malondialdehyde level, the end product of lipid peroxidation, was observed among the drug groups (G3 and G4). Furthermore, there was no statistical increase in paraoxonase level, an endogenous antioxidant enzyme, among the drug groups (G3 and G4). Thin sections of the basilar artery were morphologically examined, and severe luminal narrowing and vessel wall thickening were observed in the SAH groups (G2 and G3). In the ALA group (G4), vessel wall thickness measurements revealed no statistically significant difference compared with the other SAH groups (G2 and G3); however, G4 rats were found to have larger luminal diameters than those in G3.
Conclusion: These findings suggest that ALA had no effect on malondialdehyde-associated lipid peroxidation and paraoxonase activity; however, it had a favorable effect on basilar artery luminal diameter in the treatment of cerebral vasospasm following SAH. |
| first_indexed | 2024-04-10T12:34:36Z |
| format | Article |
| id | doaj.art-da1b61f037f24ebf94cd980e690870ed |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T12:34:36Z |
| publishDate | 2021-01-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-da1b61f037f24ebf94cd980e690870ed2023-02-15T16:14:44ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982021-01-0131431932310.14744/scie.2020.28863SCIE-28863Protective Effects of Alpha-Lipoic Acid on Cerebral Vasospasm in RatsHasan Ocak0Evren Aydoğmus1Burak Bahadır2Murat Kalaycı3Emrah Keski&775;n4Bektaş Açıkgöz5Department of Neurosurgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, TurkeyDepartment of Neurosurgery, University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Pathology, Bülent Ecevit University Faculty of Medicine, Zonguldak, TurkeyDepartment of Neurosurgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, TurkeyDepartment of Neurosurgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, TurkeyDepartment of Neurosurgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, TurkeyObjective: This study is an examination of the protective effects of alpha-lipoic acid (ALA) on cerebral vasospasm in an experimental rat model with subarachnoid hemorrhage (SAH) using biochemical, pathological, and histomorphometric analyses. Methods: A total of 28 albino Wistar rats were randomly categorized into 4 groups (n=7 each): Group (G)1, no experimental intervention; G2, subjected to SAH; G3, subjected to SAH and given physiological saline (100 mg/kg); and G4, subjected to SAH and treated with ALA (100mg/kg). Results: No statistically significant decrease in malondialdehyde level, the end product of lipid peroxidation, was observed among the drug groups (G3 and G4). Furthermore, there was no statistical increase in paraoxonase level, an endogenous antioxidant enzyme, among the drug groups (G3 and G4). Thin sections of the basilar artery were morphologically examined, and severe luminal narrowing and vessel wall thickening were observed in the SAH groups (G2 and G3). In the ALA group (G4), vessel wall thickness measurements revealed no statistically significant difference compared with the other SAH groups (G2 and G3); however, G4 rats were found to have larger luminal diameters than those in G3. Conclusion: These findings suggest that ALA had no effect on malondialdehyde-associated lipid peroxidation and paraoxonase activity; however, it had a favorable effect on basilar artery luminal diameter in the treatment of cerebral vasospasm following SAH.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-28863alpha-lipoic acidcerebral vasospasm; subarachnoid hemorrhage. |
| spellingShingle | Hasan Ocak Evren Aydoğmus Burak Bahadır Murat Kalaycı Emrah Keski&775;n Bektaş Açıkgöz Protective Effects of Alpha-Lipoic Acid on Cerebral Vasospasm in Rats Southern Clinics of Istanbul Eurasia alpha-lipoic acid cerebral vasospasm; subarachnoid hemorrhage. |
| title | Protective Effects of Alpha-Lipoic Acid on Cerebral Vasospasm in Rats |
| title_full | Protective Effects of Alpha-Lipoic Acid on Cerebral Vasospasm in Rats |
| title_fullStr | Protective Effects of Alpha-Lipoic Acid on Cerebral Vasospasm in Rats |
| title_full_unstemmed | Protective Effects of Alpha-Lipoic Acid on Cerebral Vasospasm in Rats |
| title_short | Protective Effects of Alpha-Lipoic Acid on Cerebral Vasospasm in Rats |
| title_sort | protective effects of alpha lipoic acid on cerebral vasospasm in rats |
| topic | alpha-lipoic acid cerebral vasospasm; subarachnoid hemorrhage. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-28863 |
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