Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures.
Neurocysticercosis accounts for 30%-50% of all late-onset epilepsy in endemic countries. We assessed the clustering patterns of Taenia solium human cysticercosis seropositivity and seizures around tapeworm carriers in seven rural communities in Peru.The presence of T. solium-specific antibodies was...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC2625436?pdf=render |
| _version_ | 1829134826759782400 |
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| author | Andres G Lescano Hector H Garcia Robert H Gilman Cesar M Gavidia Victor C W Tsang Silvia Rodriguez Lawrence H Moulton Manuel V Villaran Silvia M Montano Armando E Gonzalez Cysticercosis Working Group in Peru |
| author_facet | Andres G Lescano Hector H Garcia Robert H Gilman Cesar M Gavidia Victor C W Tsang Silvia Rodriguez Lawrence H Moulton Manuel V Villaran Silvia M Montano Armando E Gonzalez Cysticercosis Working Group in Peru |
| author_sort | Andres G Lescano |
| collection | DOAJ |
| description | Neurocysticercosis accounts for 30%-50% of all late-onset epilepsy in endemic countries. We assessed the clustering patterns of Taenia solium human cysticercosis seropositivity and seizures around tapeworm carriers in seven rural communities in Peru.The presence of T. solium-specific antibodies was defined as one or more positive bands in the enzyme-linked immunoelectrotransfer blot (EITB). Neurocysticercosis-related seizures cases were diagnosed clinically and had positive neuroimaging or EITB.Eleven tapeworm carriers were identified by stool microscopy. The seroprevalence of human cysticercosis was 24% (196/803). Seroprevalence was 21% >50 m from a carrier and increased to 32% at 1-50 m (p = 0.047), and from that distance seroprevalence had another significant increase to 64% at the homes of carriers (p = 0.004). Seizure prevalence was 3.0% (25/837) but there were no differences between any pair of distance ranges (p = 0.629, Wald test 2 degrees of freedom).We observed a significant human cysticercosis seroprevalence gradient surrounding current tapeworm carriers, although cysticercosis-related seizures did not cluster around carriers. Due to differences in the timing of the two outcomes, seroprevalence may reflect recent T. solium exposure more accurately than seizure frequency. |
| first_indexed | 2024-12-14T18:11:39Z |
| format | Article |
| id | doaj.art-da1d55ac832e480999be1be26627ff1f |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-14T18:11:39Z |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-da1d55ac832e480999be1be26627ff1f2022-12-21T22:52:17ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352009-01-0131e37110.1371/journal.pntd.0000371Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures.Andres G LescanoHector H GarciaRobert H GilmanCesar M GavidiaVictor C W TsangSilvia RodriguezLawrence H MoultonManuel V VillaranSilvia M MontanoArmando E GonzalezCysticercosis Working Group in PeruNeurocysticercosis accounts for 30%-50% of all late-onset epilepsy in endemic countries. We assessed the clustering patterns of Taenia solium human cysticercosis seropositivity and seizures around tapeworm carriers in seven rural communities in Peru.The presence of T. solium-specific antibodies was defined as one or more positive bands in the enzyme-linked immunoelectrotransfer blot (EITB). Neurocysticercosis-related seizures cases were diagnosed clinically and had positive neuroimaging or EITB.Eleven tapeworm carriers were identified by stool microscopy. The seroprevalence of human cysticercosis was 24% (196/803). Seroprevalence was 21% >50 m from a carrier and increased to 32% at 1-50 m (p = 0.047), and from that distance seroprevalence had another significant increase to 64% at the homes of carriers (p = 0.004). Seizure prevalence was 3.0% (25/837) but there were no differences between any pair of distance ranges (p = 0.629, Wald test 2 degrees of freedom).We observed a significant human cysticercosis seroprevalence gradient surrounding current tapeworm carriers, although cysticercosis-related seizures did not cluster around carriers. Due to differences in the timing of the two outcomes, seroprevalence may reflect recent T. solium exposure more accurately than seizure frequency.http://europepmc.org/articles/PMC2625436?pdf=render |
| spellingShingle | Andres G Lescano Hector H Garcia Robert H Gilman Cesar M Gavidia Victor C W Tsang Silvia Rodriguez Lawrence H Moulton Manuel V Villaran Silvia M Montano Armando E Gonzalez Cysticercosis Working Group in Peru Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. PLoS Neglected Tropical Diseases |
| title | Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. |
| title_full | Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. |
| title_fullStr | Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. |
| title_full_unstemmed | Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. |
| title_short | Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. |
| title_sort | taenia solium cysticercosis hotspots surrounding tapeworm carriers clustering on human seroprevalence but not on seizures |
| url | http://europepmc.org/articles/PMC2625436?pdf=render |
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