IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA
Abstract. We studied immunological state and activity of enzymes in blood lymphocytes from the patients at different stages of acute lymphoblastic leukemia. We have revealed that immune state in all the patients was characterized by decreased contents of T-lymphocytes. Upon first attack of the disea...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/265 |
| _version_ | 1797198120993423360 |
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| author | O. V. Smirnova V. T. Manchouk A. A. Savchenko |
| author_facet | O. V. Smirnova V. T. Manchouk A. A. Savchenko |
| author_sort | O. V. Smirnova |
| collection | DOAJ |
| description | Abstract. We studied immunological state and activity of enzymes in blood lymphocytes from the patients at different stages of acute lymphoblastic leukemia. We have revealed that immune state in all the patients was characterized by decreased contents of T-lymphocytes. Upon first attack of the disease, they showed a decrease in CD4+cells, as well as increased concentration of IgM and IgG. During remission, we have found the lowest values of all the parameters under study. In relapsing patients, high content of NK-cells, and imbalance between the main Ig classes were noted. When studying metabolism of lymphocyte, it was revealed that, in first attack and relapse phase, both intensity of anaerobic glucose oxidation, and levels of macromolecular synthetic reactions were decreased. In remission, all these processes did recover to normal range. At all stages of disease, glutathione reductase activity was found to be decreased in blood lymphocytes. (Med. Immunol., vol. 10, N 6, pp 543-550). |
| first_indexed | 2024-03-08T05:52:02Z |
| format | Article |
| id | doaj.art-da1e1f9e8b164d6e867ecd4b3861530b |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:49Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-da1e1f9e8b164d6e867ecd4b3861530b2024-04-22T13:07:34ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0110654355010.15789/1563-0625-2008-6-543-550262IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIAO. V. Smirnova0V. T. Manchouk1A. A. Savchenko2ГУ НИИ Медицинских проблем Севера СО РАМН, г. КрасноярскГУ НИИ Медицинских проблем Севера СО РАМН, г. КрасноярскГУ НИИ Медицинских проблем Севера СО РАМН, г. КрасноярскAbstract. We studied immunological state and activity of enzymes in blood lymphocytes from the patients at different stages of acute lymphoblastic leukemia. We have revealed that immune state in all the patients was characterized by decreased contents of T-lymphocytes. Upon first attack of the disease, they showed a decrease in CD4+cells, as well as increased concentration of IgM and IgG. During remission, we have found the lowest values of all the parameters under study. In relapsing patients, high content of NK-cells, and imbalance between the main Ig classes were noted. When studying metabolism of lymphocyte, it was revealed that, in first attack and relapse phase, both intensity of anaerobic glucose oxidation, and levels of macromolecular synthetic reactions were decreased. In remission, all these processes did recover to normal range. At all stages of disease, glutathione reductase activity was found to be decreased in blood lymphocytes. (Med. Immunol., vol. 10, N 6, pp 543-550).https://www.mimmun.ru/mimmun/article/view/265immunityacute lymphoblastic leukemiaenzymes activity |
| spellingShingle | O. V. Smirnova V. T. Manchouk A. A. Savchenko IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA Медицинская иммунология immunity acute lymphoblastic leukemia enzymes activity |
| title | IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA |
| title_full | IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA |
| title_fullStr | IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA |
| title_full_unstemmed | IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA |
| title_short | IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA |
| title_sort | immune profile and enzymes activity state in blood lymphocytes in patients of different stages acute lymphoblast leukemia |
| topic | immunity acute lymphoblastic leukemia enzymes activity |
| url | https://www.mimmun.ru/mimmun/article/view/265 |
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