Basal Cell Carcinoma: A Comprehensive Review
Basal cell carcinoma (BCC) is the most common type of carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic and genetic factors. However, despite the progress in the field, BCC biology and mechanisms of resistance against systemic treatments ha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/15/5572 |
| _version_ | 1797560433088921600 |
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| author | Emi Dika Federica Scarfì Manuela Ferracin Elisabetta Broseghini Emanuela Marcelli Barbara Bortolani Elena Campione Mattia Riefolo Costantino Ricci Martina Lambertini |
| author_facet | Emi Dika Federica Scarfì Manuela Ferracin Elisabetta Broseghini Emanuela Marcelli Barbara Bortolani Elena Campione Mattia Riefolo Costantino Ricci Martina Lambertini |
| author_sort | Emi Dika |
| collection | DOAJ |
| description | Basal cell carcinoma (BCC) is the most common type of carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic and genetic factors. However, despite the progress in the field, BCC biology and mechanisms of resistance against systemic treatments have been poorly investigated. The aim of the present review is to provide a revision of BCC histological and molecular features, including microRNA (miRNA) dysregulation, with a specific focus on the molecular basis of BCC systemic therapies. Papers from the last ten years regarding BCC genetic and phenotypic alterations, as well as the mechanism of resistance against hedgehog pathway inhibitors vismodegib and sonidegib were included. The involvement of miRNAs in BCC resistance to systemic therapies is emerging as a new field of knowledge. |
| first_indexed | 2024-03-10T17:59:32Z |
| format | Article |
| id | doaj.art-da1e392d1d63471981683a373edd8a3d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T17:59:32Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-da1e392d1d63471981683a373edd8a3d2023-11-20T09:01:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012115557210.3390/ijms21155572Basal Cell Carcinoma: A Comprehensive ReviewEmi Dika0Federica Scarfì1Manuela Ferracin2Elisabetta Broseghini3Emanuela Marcelli4Barbara Bortolani5Elena Campione6Mattia Riefolo7Costantino Ricci8Martina Lambertini9Division of Dermatology, Azienda Ospedaliero-Universitaria di Bologna, via Massarenti 9, 40138 Bologna, ItaliaDivision of Dermatology, Azienda Ospedaliero-Universitaria di Bologna, via Massarenti 9, 40138 Bologna, ItaliaDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, ItalyLaboratory of Bioengineering, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, ItalyLaboratory of Bioengineering, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, ItalyDermatology Clinic, University of Rome Tor Vergata Rome, 00133 Rome, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, ItalyOspedale Maggiore, 40133 Bologna, ItalyDivision of Dermatology, Azienda Ospedaliero-Universitaria di Bologna, via Massarenti 9, 40138 Bologna, ItaliaBasal cell carcinoma (BCC) is the most common type of carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic and genetic factors. However, despite the progress in the field, BCC biology and mechanisms of resistance against systemic treatments have been poorly investigated. The aim of the present review is to provide a revision of BCC histological and molecular features, including microRNA (miRNA) dysregulation, with a specific focus on the molecular basis of BCC systemic therapies. Papers from the last ten years regarding BCC genetic and phenotypic alterations, as well as the mechanism of resistance against hedgehog pathway inhibitors vismodegib and sonidegib were included. The involvement of miRNAs in BCC resistance to systemic therapies is emerging as a new field of knowledge.https://www.mdpi.com/1422-0067/21/15/5572basal cell carcinomamicroRNAgenetictreatmenthedgehog pathway inhibitorsvismodegib |
| spellingShingle | Emi Dika Federica Scarfì Manuela Ferracin Elisabetta Broseghini Emanuela Marcelli Barbara Bortolani Elena Campione Mattia Riefolo Costantino Ricci Martina Lambertini Basal Cell Carcinoma: A Comprehensive Review International Journal of Molecular Sciences basal cell carcinoma microRNA genetic treatment hedgehog pathway inhibitors vismodegib |
| title | Basal Cell Carcinoma: A Comprehensive Review |
| title_full | Basal Cell Carcinoma: A Comprehensive Review |
| title_fullStr | Basal Cell Carcinoma: A Comprehensive Review |
| title_full_unstemmed | Basal Cell Carcinoma: A Comprehensive Review |
| title_short | Basal Cell Carcinoma: A Comprehensive Review |
| title_sort | basal cell carcinoma a comprehensive review |
| topic | basal cell carcinoma microRNA genetic treatment hedgehog pathway inhibitors vismodegib |
| url | https://www.mdpi.com/1422-0067/21/15/5572 |
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