Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization
Ahmed M Naglah,1,2 Moamen S Refat,3,4 Mohamed A Al-Omar,1 Mashooq A Bhat,5 Hamad M AlKahtani,5 Asma S Al-Wasidi6 1Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 2Peptide Chemistry De...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-04-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/synthesis-of-a-vanadyl-iv-folate-complex-for-the-treatment-of-diabetes-peer-reviewed-article-DDDT |
| _version_ | 1819016179396640768 |
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| author | Naglah AM Refat MS Al-Omar MA Bhat MA AlKahtani HM Al-Wasidi AS |
| author_facet | Naglah AM Refat MS Al-Omar MA Bhat MA AlKahtani HM Al-Wasidi AS |
| author_sort | Naglah AM |
| collection | DOAJ |
| description | Ahmed M Naglah,1,2 Moamen S Refat,3,4 Mohamed A Al-Omar,1 Mashooq A Bhat,5 Hamad M AlKahtani,5 Asma S Al-Wasidi6 1Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 2Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Cairo 12622, Egypt; 3Chemistry Department, Faculty of Science, Taif University, Taif 21974, Saudi Arabia; 4Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt; 5Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 6Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia Background: This study aimed to design a compound with folic acid (FAH2) and vanadyl (IV) for use in the treatment of diabetes.Materials and methods: A novel vanadyl (IV) FAH2 complex was synthesized and characterized [(FA2-)(VO2+)]·3H2O. The speculated structure of this folate complex was determined using physicochemical techniques including microanalytical analysis, conductivity studies, spectroscopic examination, magnetic measurements, thermogravimetric analyses, and morphological X-ray powder diffraction, and scanning and transmission electron microscopies. The anti-diabetic therapeutic potential of the complexes was tested in a 30-day streptozotocin-induced diabetes rat model.Results: The conductivity test of the complex implied electrolyte behavior. The spectroscopic assessments of the isolated dark yellow solid complex revealed that FAH2 acts as a bidentate ligand. The coordination process with two vanadyl (IV) ions occurred through the deprotonation of both carboxyl groups of FAH2 in a regular square pyramid arrangement at a 2(FA)2-: 2(VO)2+ molar ratio. XRD, SEM, and TEM analyses revealed the complex crystalline nature of the complex. Treating diabetic rats with vanadyl (IV) FAH2 complex significantly improved many biological parameters relevant to diabetes pathology with minimal toxicity.Conclusion: The data generated in this study indicate that the synthesized vanadyl (IV) folate complex acts as a model of anti-diabetic agent. Keywords: diabetes, vanadyl, folic acid, spectroscopic, streptozotocin, vitamin B9 |
| first_indexed | 2024-12-21T02:43:31Z |
| format | Article |
| id | doaj.art-da226cdc2498409e8917409b71b95f0b |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-21T02:43:31Z |
| publishDate | 2019-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-da226cdc2498409e8917409b71b95f0b2022-12-21T19:18:37ZengDove Medical PressDrug Design, Development and Therapy1177-88812019-04-01Volume 131409142045428Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterizationNaglah AMRefat MSAl-Omar MABhat MAAlKahtani HMAl-Wasidi ASAhmed M Naglah,1,2 Moamen S Refat,3,4 Mohamed A Al-Omar,1 Mashooq A Bhat,5 Hamad M AlKahtani,5 Asma S Al-Wasidi6 1Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 2Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Cairo 12622, Egypt; 3Chemistry Department, Faculty of Science, Taif University, Taif 21974, Saudi Arabia; 4Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt; 5Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 6Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia Background: This study aimed to design a compound with folic acid (FAH2) and vanadyl (IV) for use in the treatment of diabetes.Materials and methods: A novel vanadyl (IV) FAH2 complex was synthesized and characterized [(FA2-)(VO2+)]·3H2O. The speculated structure of this folate complex was determined using physicochemical techniques including microanalytical analysis, conductivity studies, spectroscopic examination, magnetic measurements, thermogravimetric analyses, and morphological X-ray powder diffraction, and scanning and transmission electron microscopies. The anti-diabetic therapeutic potential of the complexes was tested in a 30-day streptozotocin-induced diabetes rat model.Results: The conductivity test of the complex implied electrolyte behavior. The spectroscopic assessments of the isolated dark yellow solid complex revealed that FAH2 acts as a bidentate ligand. The coordination process with two vanadyl (IV) ions occurred through the deprotonation of both carboxyl groups of FAH2 in a regular square pyramid arrangement at a 2(FA)2-: 2(VO)2+ molar ratio. XRD, SEM, and TEM analyses revealed the complex crystalline nature of the complex. Treating diabetic rats with vanadyl (IV) FAH2 complex significantly improved many biological parameters relevant to diabetes pathology with minimal toxicity.Conclusion: The data generated in this study indicate that the synthesized vanadyl (IV) folate complex acts as a model of anti-diabetic agent. Keywords: diabetes, vanadyl, folic acid, spectroscopic, streptozotocin, vitamin B9https://www.dovepress.com/synthesis-of-a-vanadyl-iv-folate-complex-for-the-treatment-of-diabetes-peer-reviewed-article-DDDTDiabetesvanadylfolic acidspectroscopicstreptozotocinVitamin B9 |
| spellingShingle | Naglah AM Refat MS Al-Omar MA Bhat MA AlKahtani HM Al-Wasidi AS Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization Drug Design, Development and Therapy Diabetes vanadyl folic acid spectroscopic streptozotocin Vitamin B9 |
| title | Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization |
| title_full | Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization |
| title_fullStr | Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization |
| title_full_unstemmed | Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization |
| title_short | Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization |
| title_sort | synthesis of a vanadyl iv folate complex for the treatment of diabetes spectroscopic structural and biological characterization |
| topic | Diabetes vanadyl folic acid spectroscopic streptozotocin Vitamin B9 |
| url | https://www.dovepress.com/synthesis-of-a-vanadyl-iv-folate-complex-for-the-treatment-of-diabetes-peer-reviewed-article-DDDT |
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