A New Test Statistic Based on Shrunken Sample Variance for Identifying Differentially Expressed Genes in Small Microarray Experiments

A New Test Statistic Based on Shrunken Sample Variance for Identifying Differentially Expressed Genes in Small Microarray Experiments

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Choosing an appropriate statistic and precisely evaluating the false discovery rate (FDR) are both essential for devising an effective method for identifying differentially expressed genes in microarray data. The t-type score proposed by Pan et al. (2003) succeeded in suppressing false positives by...

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Bibliographic Details
Main Authors: Isao Yoshimura, Chikuma Hamada, Yasunori Sato, Akihiro Hirakawa
Format: Article
Language:English
Published: SAGE Publishing 2008-01-01
Series:Bioinformatics and Biology Insights
Subjects:
differentially expressed genes
false discovery rate
microarray
shrunken sample variance
significance analysis of microarray
t-type score
Online Access:http://la-press.com/article.php?article_id=575

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