Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)
This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
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Thieme Revinter Publicações Ltda.
2015-11-01
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Series: | Sleep Science |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1984006315000590 |
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author | Edgar Garcia-Rill Brennon Luster Stasia D’Onofrio Susan Mahaffey Veronica Bisagno Francisco J. Urbano |
author_facet | Edgar Garcia-Rill Brennon Luster Stasia D’Onofrio Susan Mahaffey Veronica Bisagno Francisco J. Urbano |
author_sort | Edgar Garcia-Rill |
collection | DOAJ |
description | This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders. |
first_indexed | 2024-03-08T07:28:38Z |
format | Article |
id | doaj.art-da243a59ad10470997dc45806af5d304 |
institution | Directory Open Access Journal |
issn | 1984-0063 |
language | English |
last_indexed | 2024-03-08T07:28:38Z |
publishDate | 2015-11-01 |
publisher | Thieme Revinter Publicações Ltda. |
record_format | Article |
series | Sleep Science |
spelling | doaj.art-da243a59ad10470997dc45806af5d3042024-02-02T21:08:14ZengThieme Revinter Publicações Ltda.Sleep Science1984-00632015-11-018315316110.1016/j.slsci.2015.09.001Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)Edgar Garcia-Rill0Brennon Luster1Stasia D’Onofrio2Susan Mahaffey3Veronica Bisagno4Francisco J. Urbano5Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USACenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USACenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USACenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USAIFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, ArgentinaIFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, ArgentinaThis review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.http://www.sciencedirect.com/science/article/pii/S1984006315000590Basal forebrainCalcium channelsGamma band activityLateral hypothalamusOrexinTuberomammillary |
spellingShingle | Edgar Garcia-Rill Brennon Luster Stasia D’Onofrio Susan Mahaffey Veronica Bisagno Francisco J. Urbano Pedunculopontine arousal system physiology – Deep brain stimulation (DBS) Sleep Science Basal forebrain Calcium channels Gamma band activity Lateral hypothalamus Orexin Tuberomammillary |
title | Pedunculopontine arousal system physiology – Deep brain stimulation (DBS) |
title_full | Pedunculopontine arousal system physiology – Deep brain stimulation (DBS) |
title_fullStr | Pedunculopontine arousal system physiology – Deep brain stimulation (DBS) |
title_full_unstemmed | Pedunculopontine arousal system physiology – Deep brain stimulation (DBS) |
title_short | Pedunculopontine arousal system physiology – Deep brain stimulation (DBS) |
title_sort | pedunculopontine arousal system physiology deep brain stimulation dbs |
topic | Basal forebrain Calcium channels Gamma band activity Lateral hypothalamus Orexin Tuberomammillary |
url | http://www.sciencedirect.com/science/article/pii/S1984006315000590 |
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