Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)

This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for...

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Main Authors: Edgar Garcia-Rill, Brennon Luster, Stasia D’Onofrio, Susan Mahaffey, Veronica Bisagno, Francisco J. Urbano
Format: Article
Language:English
Published: Thieme Revinter Publicações Ltda. 2015-11-01
Series:Sleep Science
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1984006315000590
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author Edgar Garcia-Rill
Brennon Luster
Stasia D’Onofrio
Susan Mahaffey
Veronica Bisagno
Francisco J. Urbano
author_facet Edgar Garcia-Rill
Brennon Luster
Stasia D’Onofrio
Susan Mahaffey
Veronica Bisagno
Francisco J. Urbano
author_sort Edgar Garcia-Rill
collection DOAJ
description This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.
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spelling doaj.art-da243a59ad10470997dc45806af5d3042024-02-02T21:08:14ZengThieme Revinter Publicações Ltda.Sleep Science1984-00632015-11-018315316110.1016/j.slsci.2015.09.001Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)Edgar Garcia-Rill0Brennon Luster1Stasia D’Onofrio2Susan Mahaffey3Veronica Bisagno4Francisco J. Urbano5Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USACenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USACenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USACenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USAIFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, ArgentinaIFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, ArgentinaThis review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.http://www.sciencedirect.com/science/article/pii/S1984006315000590Basal forebrainCalcium channelsGamma band activityLateral hypothalamusOrexinTuberomammillary
spellingShingle Edgar Garcia-Rill
Brennon Luster
Stasia D’Onofrio
Susan Mahaffey
Veronica Bisagno
Francisco J. Urbano
Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)
Sleep Science
Basal forebrain
Calcium channels
Gamma band activity
Lateral hypothalamus
Orexin
Tuberomammillary
title Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)
title_full Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)
title_fullStr Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)
title_full_unstemmed Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)
title_short Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)
title_sort pedunculopontine arousal system physiology deep brain stimulation dbs
topic Basal forebrain
Calcium channels
Gamma band activity
Lateral hypothalamus
Orexin
Tuberomammillary
url http://www.sciencedirect.com/science/article/pii/S1984006315000590
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