Antimalarial drugs impact chemical messenger secretion by blood platelets
Background: Advances in antimalarial drug development are important for combating malaria. Among the currently identified antimalarial drugs, it is suggested that some interact directly with the malarial parasites while others interact indirectly with the parasites. While this approach leads to para...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580820300674 |
| _version_ | 1818575911264452608 |
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| author | Kang Xiong-Hang Jiayi He Kaila Kemnetz-Ness Christy Haynes |
| author_facet | Kang Xiong-Hang Jiayi He Kaila Kemnetz-Ness Christy Haynes |
| author_sort | Kang Xiong-Hang |
| collection | DOAJ |
| description | Background: Advances in antimalarial drug development are important for combating malaria. Among the currently identified antimalarial drugs, it is suggested that some interact directly with the malarial parasites while others interact indirectly with the parasites. While this approach leads to parasite elimination, little is known about how these antimalarial drugs impact immune cells that are also critical in malarial response. Methods: Herein, the effects of two common antimalarial drugs, chloroquine and quinine, on platelets were explored at both the bulk level, using high performance liquid chromatography, and the single cell level, using carbon-fiber microelectrode amperometry, to characterize any changes in chemical messenger secretion. Results: The data reveal that both drugs cause platelet activation and reduce the number of platelet exocytosis events as well as delay fusion pore opening and closing. Conclusions: This work demonstrates how chloroquine and quinine quantitatively and qualitatively impact in vitro platelet function. General significance: Overall, the goal of this work is to promote understanding about how antimalarial drugs impact platelets as this may affect antimalarial drug development as well as therapeutic approaches to treat malarial infection. |
| first_indexed | 2024-12-15T00:47:27Z |
| format | Article |
| id | doaj.art-da24af6d60a34db4853cdb915a90f190 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-15T00:47:27Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-da24af6d60a34db4853cdb915a90f1902022-12-21T22:41:31ZengElsevierBiochemistry and Biophysics Reports2405-58082020-07-0122Antimalarial drugs impact chemical messenger secretion by blood plateletsKang Xiong-Hang0Jiayi He1Kaila Kemnetz-Ness2Christy Haynes3Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455, United StatesDepartment of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455, United StatesDepartment of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455, United StatesCorresponding author.; Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455, United StatesBackground: Advances in antimalarial drug development are important for combating malaria. Among the currently identified antimalarial drugs, it is suggested that some interact directly with the malarial parasites while others interact indirectly with the parasites. While this approach leads to parasite elimination, little is known about how these antimalarial drugs impact immune cells that are also critical in malarial response. Methods: Herein, the effects of two common antimalarial drugs, chloroquine and quinine, on platelets were explored at both the bulk level, using high performance liquid chromatography, and the single cell level, using carbon-fiber microelectrode amperometry, to characterize any changes in chemical messenger secretion. Results: The data reveal that both drugs cause platelet activation and reduce the number of platelet exocytosis events as well as delay fusion pore opening and closing. Conclusions: This work demonstrates how chloroquine and quinine quantitatively and qualitatively impact in vitro platelet function. General significance: Overall, the goal of this work is to promote understanding about how antimalarial drugs impact platelets as this may affect antimalarial drug development as well as therapeutic approaches to treat malarial infection.http://www.sciencedirect.com/science/article/pii/S2405580820300674Antimalarial drugsPlateletsExocytosisCarbon-fiber microelectrode amperometryHigh-performance liquid chromatographyElectrochemistry |
| spellingShingle | Kang Xiong-Hang Jiayi He Kaila Kemnetz-Ness Christy Haynes Antimalarial drugs impact chemical messenger secretion by blood platelets Biochemistry and Biophysics Reports Antimalarial drugs Platelets Exocytosis Carbon-fiber microelectrode amperometry High-performance liquid chromatography Electrochemistry |
| title | Antimalarial drugs impact chemical messenger secretion by blood platelets |
| title_full | Antimalarial drugs impact chemical messenger secretion by blood platelets |
| title_fullStr | Antimalarial drugs impact chemical messenger secretion by blood platelets |
| title_full_unstemmed | Antimalarial drugs impact chemical messenger secretion by blood platelets |
| title_short | Antimalarial drugs impact chemical messenger secretion by blood platelets |
| title_sort | antimalarial drugs impact chemical messenger secretion by blood platelets |
| topic | Antimalarial drugs Platelets Exocytosis Carbon-fiber microelectrode amperometry High-performance liquid chromatography Electrochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2405580820300674 |
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