Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm
Background: This study aimed to introduce a novel analysis paradigm, referred to as 4-dimensional (4D) manometry based on biophysical analysis; 4D manometry enables the visualization of luminal geometry of the esophagus and esophagogastric junction (EGJ) using high-resolution-impedance-manometry (HR...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-10-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/1756284820969050 |
| _version_ | 1818450054909788160 |
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| author | Wenjun Kou Dustin A. Carlson Neelesh A. Patankar Peter J. Kahrilas John E. Pandolfino |
| author_facet | Wenjun Kou Dustin A. Carlson Neelesh A. Patankar Peter J. Kahrilas John E. Pandolfino |
| author_sort | Wenjun Kou |
| collection | DOAJ |
| description | Background: This study aimed to introduce a novel analysis paradigm, referred to as 4-dimensional (4D) manometry based on biophysical analysis; 4D manometry enables the visualization of luminal geometry of the esophagus and esophagogastric junction (EGJ) using high-resolution-impedance-manometry (HRIM) data. Methods: HRIM studies from two asymptomatic controls and one type-I achalasia patient were analyzed. Concomitant fluoroscopy images from one control subject were used to validate the calculated temporal-spatial luminal radius and time-history of intraluminal bolus volume and movement. EGJ analysis computed diameter threshold for emptying, emptying time, flow rate, and distensibility index (DI), which were compared with bolus flow time (BFT) analysis. Results: For normal control, calculated volumes for 5 ml swallows were 4.1 ml–6.7 ml; for 30 ml swallows 21.3 ml–21.8 ml. With type-I achalasia, >4 ml of intraesophageal bolus residual was present both pre- and post-swallow. The four phases of bolus transit were clearly illustrated on the time-history of bolus movement, correlating well with the fluoroscopic images. In the control subjects, the EGJ diameter threshold for emptying was 8 mm for 5 ml swallows and 10 mm for 30 ml swallows; emptying time was 1.2–2.2 s for 5 ml swallows (BFT was 0.3–3 s) and 3.25–3.75 s for 30 ml swallows; DI was 2.4–3.4 mm 2 /mmHg for 5 ml swallows and 4.2–4.6 mm 2 /mmHg for 30 ml swallows. Conclusions: The 4D manometry system facilitates a comprehensive characterization of dynamic esophageal bolus transit with concurrent luminal morphology and pressure from conventional HRIM measurements. Calculations of flow rate and wall distensibility provide novel measures of EGJ functionality. |
| first_indexed | 2024-12-14T20:45:13Z |
| format | Article |
| id | doaj.art-da2742d35e4d4c6c832d7f7b36a60218 |
| institution | Directory Open Access Journal |
| issn | 1756-2848 |
| language | English |
| last_indexed | 2024-12-14T20:45:13Z |
| publishDate | 2020-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-da2742d35e4d4c6c832d7f7b36a602182022-12-21T22:48:06ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482020-10-011310.1177/1756284820969050Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigmWenjun KouDustin A. CarlsonNeelesh A. PatankarPeter J. KahrilasJohn E. PandolfinoBackground: This study aimed to introduce a novel analysis paradigm, referred to as 4-dimensional (4D) manometry based on biophysical analysis; 4D manometry enables the visualization of luminal geometry of the esophagus and esophagogastric junction (EGJ) using high-resolution-impedance-manometry (HRIM) data. Methods: HRIM studies from two asymptomatic controls and one type-I achalasia patient were analyzed. Concomitant fluoroscopy images from one control subject were used to validate the calculated temporal-spatial luminal radius and time-history of intraluminal bolus volume and movement. EGJ analysis computed diameter threshold for emptying, emptying time, flow rate, and distensibility index (DI), which were compared with bolus flow time (BFT) analysis. Results: For normal control, calculated volumes for 5 ml swallows were 4.1 ml–6.7 ml; for 30 ml swallows 21.3 ml–21.8 ml. With type-I achalasia, >4 ml of intraesophageal bolus residual was present both pre- and post-swallow. The four phases of bolus transit were clearly illustrated on the time-history of bolus movement, correlating well with the fluoroscopic images. In the control subjects, the EGJ diameter threshold for emptying was 8 mm for 5 ml swallows and 10 mm for 30 ml swallows; emptying time was 1.2–2.2 s for 5 ml swallows (BFT was 0.3–3 s) and 3.25–3.75 s for 30 ml swallows; DI was 2.4–3.4 mm 2 /mmHg for 5 ml swallows and 4.2–4.6 mm 2 /mmHg for 30 ml swallows. Conclusions: The 4D manometry system facilitates a comprehensive characterization of dynamic esophageal bolus transit with concurrent luminal morphology and pressure from conventional HRIM measurements. Calculations of flow rate and wall distensibility provide novel measures of EGJ functionality.https://doi.org/10.1177/1756284820969050 |
| spellingShingle | Wenjun Kou Dustin A. Carlson Neelesh A. Patankar Peter J. Kahrilas John E. Pandolfino Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm Therapeutic Advances in Gastroenterology |
| title | Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm |
| title_full | Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm |
| title_fullStr | Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm |
| title_full_unstemmed | Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm |
| title_short | Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm |
| title_sort | four dimensional impedance manometry derived from esophageal high resolution impedance manometry studies a novel analysis paradigm |
| url | https://doi.org/10.1177/1756284820969050 |
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