Cannabinoid Modulation of the Stressed Hippocampus
Exposure to stressful situations is one of the risk factors for the precipitation of several psychiatric disorders, including Major Depressive Disorder, Posttraumatic Stress Disorder and Schizophrenia. The hippocampal formation is a forebrain structure highly associated with emotional, learning and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00411/full |
| _version_ | 1818858195085426688 |
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| author | Franciele F. Scarante Carla Vila-Verde Vinícius L. Detoni Nilson C. Ferreira-Junior Francisco S. Guimarães Alline C. Campos |
| author_facet | Franciele F. Scarante Carla Vila-Verde Vinícius L. Detoni Nilson C. Ferreira-Junior Francisco S. Guimarães Alline C. Campos |
| author_sort | Franciele F. Scarante |
| collection | DOAJ |
| description | Exposure to stressful situations is one of the risk factors for the precipitation of several psychiatric disorders, including Major Depressive Disorder, Posttraumatic Stress Disorder and Schizophrenia. The hippocampal formation is a forebrain structure highly associated with emotional, learning and memory processes; being particularly vulnerable to stress. Exposure to stressful stimuli leads to neuroplastic changes and imbalance between inhibitory/excitatory networks. These changes have been associated with an impaired hippocampal function. Endocannabinoids (eCB) are one of the main systems controlling both excitatory and inhibitory neurotransmission, as well as neuroplasticity within the hippocampus. Cannabinoids receptors are highly expressed in the hippocampus, and several lines of evidence suggest that facilitation of cannabinoid signaling within this brain region prevents stress-induced behavioral changes. Also, chronic stress modulates hippocampal CB1 receptors expression and endocannabinoid levels. Moreover, cannabinoids participate in mechanisms related to synaptic plasticity and adult neurogenesis. Here, we discussed the main findings supporting the involvement of hippocampal cannabinoid neurotransmission in stress-induced behavioral and neuroplastic changes. |
| first_indexed | 2024-12-19T08:52:25Z |
| format | Article |
| id | doaj.art-da28456a38d641108ce60f54ba880b37 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-19T08:52:25Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-da28456a38d641108ce60f54ba880b372022-12-21T20:28:41ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992017-12-011010.3389/fnmol.2017.00411315348Cannabinoid Modulation of the Stressed HippocampusFranciele F. Scarante0Carla Vila-Verde1Vinícius L. Detoni2Nilson C. Ferreira-Junior3Francisco S. Guimarães4Alline C. Campos5epartment of Pharmacology, School of Medicine of Ribeirão Preto, Centre for Interdisciplinary Research on Applied Neurosciences (NAPNA), Cannabinoid Research Institute, University of São Paulo, São Paulo, Brazilepartment of Pharmacology, School of Medicine of Ribeirão Preto, Centre for Interdisciplinary Research on Applied Neurosciences (NAPNA), Cannabinoid Research Institute, University of São Paulo, São Paulo, Brazilepartment of Pharmacology, School of Medicine of Ribeirão Preto, Centre for Interdisciplinary Research on Applied Neurosciences (NAPNA), Cannabinoid Research Institute, University of São Paulo, São Paulo, Brazilepartment of Pharmacology, School of Medicine of Ribeirão Preto, Centre for Interdisciplinary Research on Applied Neurosciences (NAPNA), Cannabinoid Research Institute, University of São Paulo, São Paulo, Brazilepartment of Pharmacology, School of Medicine of Ribeirão Preto, Centre for Interdisciplinary Research on Applied Neurosciences (NAPNA), Cannabinoid Research Institute, University of São Paulo, São Paulo, Brazilepartment of Pharmacology, School of Medicine of Ribeirão Preto, Centre for Interdisciplinary Research on Applied Neurosciences (NAPNA), Cannabinoid Research Institute, University of São Paulo, São Paulo, BrazilExposure to stressful situations is one of the risk factors for the precipitation of several psychiatric disorders, including Major Depressive Disorder, Posttraumatic Stress Disorder and Schizophrenia. The hippocampal formation is a forebrain structure highly associated with emotional, learning and memory processes; being particularly vulnerable to stress. Exposure to stressful stimuli leads to neuroplastic changes and imbalance between inhibitory/excitatory networks. These changes have been associated with an impaired hippocampal function. Endocannabinoids (eCB) are one of the main systems controlling both excitatory and inhibitory neurotransmission, as well as neuroplasticity within the hippocampus. Cannabinoids receptors are highly expressed in the hippocampus, and several lines of evidence suggest that facilitation of cannabinoid signaling within this brain region prevents stress-induced behavioral changes. Also, chronic stress modulates hippocampal CB1 receptors expression and endocannabinoid levels. Moreover, cannabinoids participate in mechanisms related to synaptic plasticity and adult neurogenesis. Here, we discussed the main findings supporting the involvement of hippocampal cannabinoid neurotransmission in stress-induced behavioral and neuroplastic changes.http://journal.frontiersin.org/article/10.3389/fnmol.2017.00411/fullhippocampusstressHPA axisendocannabinoid systemCB1CB2 |
| spellingShingle | Franciele F. Scarante Carla Vila-Verde Vinícius L. Detoni Nilson C. Ferreira-Junior Francisco S. Guimarães Alline C. Campos Cannabinoid Modulation of the Stressed Hippocampus Frontiers in Molecular Neuroscience hippocampus stress HPA axis endocannabinoid system CB1 CB2 |
| title | Cannabinoid Modulation of the Stressed Hippocampus |
| title_full | Cannabinoid Modulation of the Stressed Hippocampus |
| title_fullStr | Cannabinoid Modulation of the Stressed Hippocampus |
| title_full_unstemmed | Cannabinoid Modulation of the Stressed Hippocampus |
| title_short | Cannabinoid Modulation of the Stressed Hippocampus |
| title_sort | cannabinoid modulation of the stressed hippocampus |
| topic | hippocampus stress HPA axis endocannabinoid system CB1 CB2 |
| url | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00411/full |
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