Development of Human Cell-Based In Vitro Infection Models to Determine the Intracellular Survival of Mycobacterium avium

Development of Human Cell-Based In Vitro Infection Models to Determine the Intracellular Survival of Mycobacterium avium

The Mycobacterium avium (Mav) complex accounts for more than 80% of all pulmonary diseases caused by non-tuberculous mycobacteria (NTM) infections, which have an alarming increase in prevalence and vary in different regions, currently reaching 0.3–9.8 per 100,000 individuals. Poor clinical outcomes,...

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Bibliographic Details
Main Authors: Gül Kilinç, Kimberley V. Walburg, Kees L. M. C. Franken, Merel L. Valkenburg, Alexandra Aubry, Mariëlle C. Haks, Anno Saris, Tom H. M. Ottenhoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium avium
primary human macrophages
infection models
drug susceptibility assays
MGIT 960 system
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.872361/full

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