High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome.
To evaluate the relationship between metabolic syndrome (MetS) and the prevalence of diabetic retinopathy (DR).We conducted a case-controlled study, with data obtained from 2,551 Chinese participants between 18-79 years of age (representing a population of 1,660,500 in a district of Beijing). 74 cas...
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| Format: | Article |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4712887?pdf=render |
| _version_ | 1819168431477358592 |
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| author | Lu Gao Zhong Xin Ming-Xia Yuan Xi Cao Jian-Ping Feng Jing Shi Xiao-Rong Zhu Jin-Kui Yang |
| author_facet | Lu Gao Zhong Xin Ming-Xia Yuan Xi Cao Jian-Ping Feng Jing Shi Xiao-Rong Zhu Jin-Kui Yang |
| author_sort | Lu Gao |
| collection | DOAJ |
| description | To evaluate the relationship between metabolic syndrome (MetS) and the prevalence of diabetic retinopathy (DR).We conducted a case-controlled study, with data obtained from 2,551 Chinese participants between 18-79 years of age (representing a population of 1,660,500 in a district of Beijing). 74 cases of DR were found following data assessment by two 45° digital retinal images. Subjects without DR (NDR group) selected from the remaining 2,477 subjects were matched 1:1 to the DR group by HbA1c. MetS was defined by incorporating diagnostic criteria of the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and the International Diabetes Federation (IDF).There were no statistical differences between the DR group and NDR group in a number of biological or laboratory tests. However, the percentage of patients with DR increased vs. patients without DR with the number of MetS components from 1 to 5 (14.3% vs. 85.7%, 38.9% vs. 61.1%, 49.1% vs. 50.9%, 61.4% vs. 38.6% and 83.3% vs. 16.7%, respectively) (Pearson χ2 = 9.938, P = 0.037). The trend to develop DR with MetS was significantly higher than that without MetS (NMetS) (χ2 = 5.540, P = 0.019). MetS was an independent statistical indicator of the presence of DR after adjusting for age and sex [odds ratio (95% CI): 2.701(1.248-5.849), P = 0.012], which is still the case with an additional adjustment for WC, SBP, TC, HbA1c and duration of diabetes [odds ratio (95% CI): 2.948(1.134-7.664), P = 0.027].DR is one of the diabetic microvascular complications. Apart from poor glycemic control, the concomitance of other metabolic factors can also influence DR. MetS, defined as a cluster of metabolic risk factors, is a strong and independent indicator of DR, even to the same extent as glycemic control. |
| first_indexed | 2024-12-22T19:03:30Z |
| format | Article |
| id | doaj.art-da29acc5dd28439b87bdd8177059b722 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T19:03:30Z |
| publishDate | 2016-01-01 |
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| series | PLoS ONE |
| spelling | doaj.art-da29acc5dd28439b87bdd8177059b7222022-12-21T18:15:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014529310.1371/journal.pone.0145293High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome.Lu GaoZhong XinMing-Xia YuanXi CaoJian-Ping FengJing ShiXiao-Rong ZhuJin-Kui YangTo evaluate the relationship between metabolic syndrome (MetS) and the prevalence of diabetic retinopathy (DR).We conducted a case-controlled study, with data obtained from 2,551 Chinese participants between 18-79 years of age (representing a population of 1,660,500 in a district of Beijing). 74 cases of DR were found following data assessment by two 45° digital retinal images. Subjects without DR (NDR group) selected from the remaining 2,477 subjects were matched 1:1 to the DR group by HbA1c. MetS was defined by incorporating diagnostic criteria of the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and the International Diabetes Federation (IDF).There were no statistical differences between the DR group and NDR group in a number of biological or laboratory tests. However, the percentage of patients with DR increased vs. patients without DR with the number of MetS components from 1 to 5 (14.3% vs. 85.7%, 38.9% vs. 61.1%, 49.1% vs. 50.9%, 61.4% vs. 38.6% and 83.3% vs. 16.7%, respectively) (Pearson χ2 = 9.938, P = 0.037). The trend to develop DR with MetS was significantly higher than that without MetS (NMetS) (χ2 = 5.540, P = 0.019). MetS was an independent statistical indicator of the presence of DR after adjusting for age and sex [odds ratio (95% CI): 2.701(1.248-5.849), P = 0.012], which is still the case with an additional adjustment for WC, SBP, TC, HbA1c and duration of diabetes [odds ratio (95% CI): 2.948(1.134-7.664), P = 0.027].DR is one of the diabetic microvascular complications. Apart from poor glycemic control, the concomitance of other metabolic factors can also influence DR. MetS, defined as a cluster of metabolic risk factors, is a strong and independent indicator of DR, even to the same extent as glycemic control.http://europepmc.org/articles/PMC4712887?pdf=render |
| spellingShingle | Lu Gao Zhong Xin Ming-Xia Yuan Xi Cao Jian-Ping Feng Jing Shi Xiao-Rong Zhu Jin-Kui Yang High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome. PLoS ONE |
| title | High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome. |
| title_full | High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome. |
| title_fullStr | High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome. |
| title_full_unstemmed | High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome. |
| title_short | High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome. |
| title_sort | high prevalence of diabetic retinopathy in diabetic patients concomitant with metabolic syndrome |
| url | http://europepmc.org/articles/PMC4712887?pdf=render |
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