Role of Animal Models in Periodontal Clinical Research and its Present-Day Status: A Narrative Review
The use of animal models have aided in the development of new information in periodontology research. Animal models enable legal acceptance of human welfare. Dogs, rats, ferrets, hamsters, mice and on rare occasions, rabbits and sheep have been used to study human periodontal diseases. Animal models...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/17643/61707_CE[Ra1]_F(IS)_PF1(TY_IS)_PFA(TY_KM)_PN(KM).pdf |
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| author | Muskan Baheti Khushboo Durge Pavan Bajaj Bhairavi Kale Unnati Shirbhate |
| author_facet | Muskan Baheti Khushboo Durge Pavan Bajaj Bhairavi Kale Unnati Shirbhate |
| author_sort | Muskan Baheti |
| collection | DOAJ |
| description | The use of animal models have aided in the development of new information in periodontology research. Animal models enable legal acceptance of human welfare. Dogs, rats, ferrets, hamsters, mice and on rare occasions, rabbits and sheep have been used to study human periodontal diseases. Animal models were chosen because they have similar anatomical and physiological features of the oral cavity and periodontium, as well as the presence of causative agents that contribute to the occurrence of natural periodontal disease in humans. There has been a progression toward the development of a feasible and sufficiently accurate model that accurately reflects the true pathogenic mechanisms of living person periodontal disease. Non human primates have been used extensively in periodontal investigations as well as in medical technology to understand the origin of periodontal disease. Caries and calculus study is best accomplished through hamsters and rat. Periodontal disease and calculus formation in ferrets could be potential and encouraging in the research area. Thus, the structural and pathophysiology of the animal kingdom differs from that of human beings and seems sometimes troublesome with the latest therapies. Hamster stays an intriguing model for immunological studies. New possibilities in the periodontal analysis are now accessible, enabling broader cohorts that are easier to build. The goal of this review is to give an overview of the animal models that have been employed in the periodontal investigation. The purpose of this review is to identify the best animal model for periodontal research and also for the safety precautions for human beings. The use of fact-finding models used in periodontal disease is crucial to grasp the root source in the human being. Animal models are beneficial in periodontal surveys and an unavoidable step before accessing clinical testing with the latest biomaterials and therapies. |
| first_indexed | 2024-04-09T20:08:04Z |
| format | Article |
| id | doaj.art-da2b282c819046a491bc212f78ba0d06 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-09T20:08:04Z |
| publishDate | 2023-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-da2b282c819046a491bc212f78ba0d062023-04-01T10:11:12ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-03-01173ZE19ZE2210.7860/JCDR/2023/61707.17643Role of Animal Models in Periodontal Clinical Research and its Present-Day Status: A Narrative ReviewMuskan Baheti0Khushboo Durge1Pavan Bajaj2Bhairavi Kale3Unnati Shirbhate4Intern, Department of Periodontics and Implantology, Sharad Pawar Dental College, Sawangi, Wardha, Maharashtra, India.Assistant Professor, Department of Periodontics and Implantology, Sharad Pawar Dental College, Sawangi, Wardha, Maharashtra, India.Associate Professor, Department of Periodontics and Implantology, Sharad Pawar Dental College, Sawangi, Wardha, Maharashtra, India.Assistant Professor, Department of Periodontics and Implantology, Sharad Pawar Dental College, Sawangi, Wardha, Maharashtra, India.Postgraduate Student, Department of Periodontics and Implantology, Sharad Pawar Dental College, Sawangi, Amravati, Maharashtra, India.The use of animal models have aided in the development of new information in periodontology research. Animal models enable legal acceptance of human welfare. Dogs, rats, ferrets, hamsters, mice and on rare occasions, rabbits and sheep have been used to study human periodontal diseases. Animal models were chosen because they have similar anatomical and physiological features of the oral cavity and periodontium, as well as the presence of causative agents that contribute to the occurrence of natural periodontal disease in humans. There has been a progression toward the development of a feasible and sufficiently accurate model that accurately reflects the true pathogenic mechanisms of living person periodontal disease. Non human primates have been used extensively in periodontal investigations as well as in medical technology to understand the origin of periodontal disease. Caries and calculus study is best accomplished through hamsters and rat. Periodontal disease and calculus formation in ferrets could be potential and encouraging in the research area. Thus, the structural and pathophysiology of the animal kingdom differs from that of human beings and seems sometimes troublesome with the latest therapies. Hamster stays an intriguing model for immunological studies. New possibilities in the periodontal analysis are now accessible, enabling broader cohorts that are easier to build. The goal of this review is to give an overview of the animal models that have been employed in the periodontal investigation. The purpose of this review is to identify the best animal model for periodontal research and also for the safety precautions for human beings. The use of fact-finding models used in periodontal disease is crucial to grasp the root source in the human being. Animal models are beneficial in periodontal surveys and an unavoidable step before accessing clinical testing with the latest biomaterials and therapies.https://www.jcdr.net/articles/PDF/17643/61707_CE[Ra1]_F(IS)_PF1(TY_IS)_PFA(TY_KM)_PN(KM).pdfdogshamstershostmiceperiodontal disease |
| spellingShingle | Muskan Baheti Khushboo Durge Pavan Bajaj Bhairavi Kale Unnati Shirbhate Role of Animal Models in Periodontal Clinical Research and its Present-Day Status: A Narrative Review Journal of Clinical and Diagnostic Research dogs hamsters host mice periodontal disease |
| title | Role of Animal Models in Periodontal Clinical Research and its Present-Day Status: A Narrative Review |
| title_full | Role of Animal Models in Periodontal Clinical Research and its Present-Day Status: A Narrative Review |
| title_fullStr | Role of Animal Models in Periodontal Clinical Research and its Present-Day Status: A Narrative Review |
| title_full_unstemmed | Role of Animal Models in Periodontal Clinical Research and its Present-Day Status: A Narrative Review |
| title_short | Role of Animal Models in Periodontal Clinical Research and its Present-Day Status: A Narrative Review |
| title_sort | role of animal models in periodontal clinical research and its present day status a narrative review |
| topic | dogs hamsters host mice periodontal disease |
| url | https://www.jcdr.net/articles/PDF/17643/61707_CE[Ra1]_F(IS)_PF1(TY_IS)_PFA(TY_KM)_PN(KM).pdf |
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