A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates

A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates

Summary: Zika virus (ZIKV) causes severe neurologic complications and fetal aberrations. Vaccine development is hindered by potential safety concerns due to antibody cross-reactivity with dengue virus and the possibility of disease enhancement. In contrast, passive administration of anti-ZIKV antibo...

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Main Authors: Jennifer R. Keeffe, Koen K.A. Van Rompay, Priscilla C. Olsen, Qiao Wang, Anna Gazumyan, Stephanie A. Azzopardi, Dennis Schaefer-Babajew, Yu E. Lee, Jackson B. Stuart, Anil Singapuri, Jennifer Watanabe, Jodie Usachenko, Amir Ardeshir, Mohsan Saeed, Marianna Agudelo, Thomas Eisenreich, Stylianos Bournazos, Thiago Y. Oliveira, Charles M. Rice, Lark L. Coffey, Margaret R. MacDonald, Pamela J. Bjorkman, Michel C. Nussenzweig, Davide F. Robbiani
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316073

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