Melittin-Based Nano-Delivery Systems for Cancer Therapy
Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its se...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/1/118 |
| _version_ | 1797495497426993152 |
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| author | Anqi Wang Yuan Zheng Wanxin Zhu Liuxin Yang Yang Yang Jinliang Peng |
| author_facet | Anqi Wang Yuan Zheng Wanxin Zhu Liuxin Yang Yang Yang Jinliang Peng |
| author_sort | Anqi Wang |
| collection | DOAJ |
| description | Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its severe hemolytic activity. Different nanocarrier systems have been developed to achieve stable loading, side effects shielding, and tumor-targeted delivery, such as liposomes, cationic polymers, lipodisks, etc. In addition, MEL can be modified on nano drugs as a non-selective cytolytic peptide to enhance cellular uptake and endosomal/lysosomal escape. In this review, we discuss recent advances in MEL’s nano-delivery systems and MEL-modified nano drug carriers for cancer therapy. |
| first_indexed | 2024-03-10T01:50:27Z |
| format | Article |
| id | doaj.art-da2d2ecaff3d4eeebbd51cf0af6a80d1 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:50:27Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-da2d2ecaff3d4eeebbd51cf0af6a80d12023-11-23T13:07:20ZengMDPI AGBiomolecules2218-273X2022-01-0112111810.3390/biom12010118Melittin-Based Nano-Delivery Systems for Cancer TherapyAnqi Wang0Yuan Zheng1Wanxin Zhu2Liuxin Yang3Yang Yang4Jinliang Peng5School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, ChinaMelittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its severe hemolytic activity. Different nanocarrier systems have been developed to achieve stable loading, side effects shielding, and tumor-targeted delivery, such as liposomes, cationic polymers, lipodisks, etc. In addition, MEL can be modified on nano drugs as a non-selective cytolytic peptide to enhance cellular uptake and endosomal/lysosomal escape. In this review, we discuss recent advances in MEL’s nano-delivery systems and MEL-modified nano drug carriers for cancer therapy.https://www.mdpi.com/2218-273X/12/1/118melittinhemolysisstable loadingnano-delivery systemtumor therapy |
| spellingShingle | Anqi Wang Yuan Zheng Wanxin Zhu Liuxin Yang Yang Yang Jinliang Peng Melittin-Based Nano-Delivery Systems for Cancer Therapy Biomolecules melittin hemolysis stable loading nano-delivery system tumor therapy |
| title | Melittin-Based Nano-Delivery Systems for Cancer Therapy |
| title_full | Melittin-Based Nano-Delivery Systems for Cancer Therapy |
| title_fullStr | Melittin-Based Nano-Delivery Systems for Cancer Therapy |
| title_full_unstemmed | Melittin-Based Nano-Delivery Systems for Cancer Therapy |
| title_short | Melittin-Based Nano-Delivery Systems for Cancer Therapy |
| title_sort | melittin based nano delivery systems for cancer therapy |
| topic | melittin hemolysis stable loading nano-delivery system tumor therapy |
| url | https://www.mdpi.com/2218-273X/12/1/118 |
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