Melittin-Based Nano-Delivery Systems for Cancer Therapy

Melittin-Based Nano-Delivery Systems for Cancer Therapy

Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its se...

Full description

Bibliographic Details
Main Authors:	Anqi Wang, Yuan Zheng, Wanxin Zhu, Liuxin Yang, Yang Yang, Jinliang Peng
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	Biomolecules
Subjects:	melittin hemolysis stable loading nano-delivery system tumor therapy
Online Access:	https://www.mdpi.com/2218-273X/12/1/118

Similar Items

Genetically engineered nano‐melittin vesicles for multimodal synergetic cancer therapy
by: Jianzhong Zhang, et al.
Published: (2023-11-01)

Redox-Sensitive Nanocomplex for Targeted Delivery of Melittin
by: Bei Cheng, et al.
Published: (2020-09-01)

A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety
by: Jie Mao, et al.
Published: (2017-03-01)

New N-Terminal Fatty-Acid-Modified Melittin Analogs with Potent Biological Activity
by: Sheng Huang, et al.
Published: (2024-01-01)

Delivery of Melittin as a Lytic Agent via Graphene Nanoparticles as Carriers to Breast Cancer Cells
by: Karolina Daniluk, et al.
Published: (2022-12-01)

SiO2–alginate–melittin nano-conjugates suppress the proliferation of ovarian cancer cells: a controlled release approach leveraging alginate lyase
by: Lihui Si, et al.
Published: (2024-01-01)

Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
by: Xiang Yu, et al.
Published: (2023-11-01)

Emulsion-Based Intradermal Delivery of Melittin in Rats
by: Sang Mi Han, et al.
Published: (2017-05-01)

Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect
by: Farnaz Dabbagh Moghaddam, et al.
Published: (2021-06-01)

Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates
by: Shaimaa M. Badr-Eldin, et al.
Published: (2021-02-01)

Effect of Melittin Complexes with Graphene and Graphene Oxide on Triple-Negative Breast Cancer Tumors Grown on Chicken Embryo Chorioallantoic Membrane
by: Karolina Daniluk, et al.
Published: (2023-05-01)

The Pharmacological Potential of Novel Melittin Variants from the Honeybee and Solitary Bees against Inflammation and Cancer
by: Pelin Erkoc, et al.
Published: (2022-11-01)

An Insight into the Role of Bee Venom and Melittin Against Tumor Cells: A Review of Breast Cancer therapy
by: Roha Tariq, et al.
Published: (2021-10-01)

Bioinformatics Study of the Interaction between Melittin Protein and P24 Protein in HIV and SIV Viruses
by: Zahra Hasanshahi, et al.
Published: (2022-11-01)

The Protective Effect of Melittin on Renal Fibrosis in an Animal Model of Unilateral Ureteral Obstruction
by: Hyun-Jin An, et al.
Published: (2016-08-01)

Comparative Determination of Melittin by Capillary Electrophoretic Methods
by: Melda AKAY, et al.
Published: (2021-11-01)

Design and activity study of a melittin–thanatin hybrid peptide
by: Xiaofeng Jiang, et al.
Published: (2019-01-01)

Anti-Inflammatory Applications of Melittin, a Major Component of Bee Venom: Detailed Mechanism of Action and Adverse Effects
by: Gihyun Lee, et al.
Published: (2016-05-01)

Effective treatment of metastatic sentinel lymph nodes by dual-targeting melittin nanoparticles
by: Yanfeng Dai, et al.
Published: (2023-08-01)

Melittin promotes dexamethasone in the treatment of adjuvant rheumatoid arthritis in rats
by: Linfu Yang, et al.
Published: (2024-02-01)

Therapeutic Effect of Melittin–dKLA Targeting Tumor-Associated Macrophages in Melanoma
by: Ik-Hwan Han, et al.
Published: (2022-03-01)

Effects of Melittin Treatment in Cholangitis and Biliary Fibrosis in a Model of Xenobiotic-Induced Cholestasis in Mice
by: Kyung-Hyun Kim, et al.
Published: (2015-08-01)

Aptamer AS1411-functionalized gold nanoparticle-melittin complex for targeting MCF-7 breast cancer cell line
by: Payam Bayat, et al.
Published: (2022-04-01)

Effects of melittin on laying performance and intestinal barrier function of quails
by: Zhili Li, et al.
Published: (2023-02-01)

Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitis
by: Brenda Fernanda Moreira Castro, et al.
Published: (2022-01-01)

Therapeutic evaluation of activatable melittin for selective treatment of leishmaniasis in vitro and in vivo
by: S. Akhzari, et al.
Published: (2024-03-01)

Cordycepin- melittin nanoconjugate intensifies wound healing efficacy in diabetic rats
by: Rasheed A. Shaik, et al.
Published: (2023-05-01)

Isolating Melittin from Bee Venom and Evaluating its Effect on Proliferation of Gastric Cancer Cells
by: Amir Mahmoodzadeh, et al.
Published: (2013-10-01)

Melittin as a promising anti-protozoan peptide: current knowledge and future prospects
by: Hamed Memariani, et al.
Published: (2021-05-01)

Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells
by: Nabil A. Alhakamy, et al.
Published: (2021-12-01)

Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan
by: Miguel Moreno, et al.
Published: (2015-04-01)

Inorganic nano-carriers based smart drug delivery systems for tumor therapy
by: Zhaoqing Shi, et al.
Published: (2020-01-01)

Enhanced Therapeutic Effect of Optimized Melittin-dKLA, a Peptide Agent Targeting M2-like Tumor-Associated Macrophages in Triple-Negative Breast Cancer
by: Soyoung Kim, et al.
Published: (2022-12-01)

Qualitative and quantitative evaluation of melittin in honeybee venom and drug products containing honeybee venom
by: Haghi Ghasem, et al.
Published: (2013-12-01)

Enhanced healing efficacy of an optimized gabapentin-melittin nanoconjugate gel-loaded formulation in excised wounds of diabetic rats
by: Hani Z. Asfour, et al.
Published: (2022-12-01)

The Effect of Melittin on Rac1 Protein Expression as a Metastatic Factor in AGS Gastric Cancer Cell Lines
by: M Hemati, et al.
Published: (2014-06-01)

Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide
by: Chanju Lee, et al.
Published: (2019-06-01)

Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis
by: Hongyan Zan, et al.
Published: (2024-12-01)

Research Progress on Gene Editing Based on Nano-Drug Delivery Vectors for Tumor Therapy
by: Shiwen Xi, et al.
Published: (2022-03-01)

Evaluation of the Effect of Liposome Carriers and Albumin Nanoparticles Containing Activated Melittin on Inhibiting the Growth of Leishmania Major Amastigote in vivo
by: Soheila Akhzari, et al.
Published: (2021-12-01)