Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study
Objectives: NREM parasomnias also known as disorders of arousal (DOA) are characterised by abnormal motor and autonomic activation during arousals primarily from slow wave sleep. Dissociative state between sleep and wake is likely responsible for clinical symptoms of DOA. We therefore investigated p...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Sleep Medicine: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590142723000265 |
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| author | E. Miletínová M. Piorecký V. Koudelka S. Jiříček D. Tomeček M. Brunovský J. Horáček J. Bušková |
| author_facet | E. Miletínová M. Piorecký V. Koudelka S. Jiříček D. Tomeček M. Brunovský J. Horáček J. Bušková |
| author_sort | E. Miletínová |
| collection | DOAJ |
| description | Objectives: NREM parasomnias also known as disorders of arousal (DOA) are characterised by abnormal motor and autonomic activation during arousals primarily from slow wave sleep. Dissociative state between sleep and wake is likely responsible for clinical symptoms of DOA. We therefore investigated potential dissociation outside of parasomnic events by using simultaneous 256-channel EEG (hdEEG) and functional magnetic resonance imaging (fMRI). Methods: Eight DOA patients (3 women, mean age = 27.8; SD = 4.2) and 8 gender and age matched healthy volunteers (3 women, mean age = 26,5; SD = 4.0) were included into the study. They underwent 30–32 h of sleep deprivation followed by hdEEG and fMRI recording. We determined 2 conditions: falling asleep (FA) and arousal (A), that occurred outside of deep sleep and/or parasomnic event. We used multimodal approach using data obtained from EEG, fMRI and EEG-fMRI integration approach. Results: DOA patients showed increase in delta and beta activity over postcentral gyrus and cuneus during awakening period. This group expressed increased connectivity between motor cortex and cingulate during arousals unrelated to parasomnic events in the beta frequency band. They also showed lower connectivity between different portions of cingulum. In contrast, the greater connectivity was found between thalamus and some cortical areas, such as occipital cortex. Conclusion: Our findings suggest a complex alteration in falling asleep and arousal mechanisms at both subcortical and cortical levels in response to sleep deprivation. As this alteration is present also outside of slow wave sleep and/or parasomnic episodes we believe this could be a trait factor of DOA. |
| first_indexed | 2024-03-09T01:34:37Z |
| format | Article |
| id | doaj.art-da2d922b190b4432a52f31c882f135a0 |
| institution | Directory Open Access Journal |
| issn | 2590-1427 |
| language | English |
| last_indexed | 2024-03-09T01:34:37Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sleep Medicine: X |
| spelling | doaj.art-da2d922b190b4432a52f31c882f135a02023-12-09T06:07:45ZengElsevierSleep Medicine: X2590-14272023-12-016100086Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot studyE. Miletínová0M. Piorecký1V. Koudelka2S. Jiříček3D. Tomeček4M. Brunovský5J. Horáček6J. Bušková7National Institute of Mental Health, Topolova 748, Klecany, Czech Republic; Third Faculty of Medicine, Charles University in Prague, Ruská 87, Prague, Czech Republic; Corresponding author. National Institute of Mental Health, Topolova 748, Klecany, Czech Republic.National Institute of Mental Health, Topolova 748, Klecany, Czech Republic; Department of Biomedical Technology, Faculty of Biomedical Engineering, CTU in Prague, Czech RepublicNational Institute of Mental Health, Topolova 748, Klecany, Czech Republic; Department of Biomedical Technology, Faculty of Biomedical Engineering, CTU in Prague, Czech RepublicNational Institute of Mental Health, Topolova 748, Klecany, Czech Republic; Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech RepublicNational Institute of Mental Health, Topolova 748, Klecany, Czech Republic; Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech RepublicNational Institute of Mental Health, Topolova 748, Klecany, Czech Republic; Third Faculty of Medicine, Charles University in Prague, Ruská 87, Prague, Czech RepublicNational Institute of Mental Health, Topolova 748, Klecany, Czech Republic; Third Faculty of Medicine, Charles University in Prague, Ruská 87, Prague, Czech RepublicNational Institute of Mental Health, Topolova 748, Klecany, Czech Republic; Third Faculty of Medicine, Charles University in Prague, Ruská 87, Prague, Czech RepublicObjectives: NREM parasomnias also known as disorders of arousal (DOA) are characterised by abnormal motor and autonomic activation during arousals primarily from slow wave sleep. Dissociative state between sleep and wake is likely responsible for clinical symptoms of DOA. We therefore investigated potential dissociation outside of parasomnic events by using simultaneous 256-channel EEG (hdEEG) and functional magnetic resonance imaging (fMRI). Methods: Eight DOA patients (3 women, mean age = 27.8; SD = 4.2) and 8 gender and age matched healthy volunteers (3 women, mean age = 26,5; SD = 4.0) were included into the study. They underwent 30–32 h of sleep deprivation followed by hdEEG and fMRI recording. We determined 2 conditions: falling asleep (FA) and arousal (A), that occurred outside of deep sleep and/or parasomnic event. We used multimodal approach using data obtained from EEG, fMRI and EEG-fMRI integration approach. Results: DOA patients showed increase in delta and beta activity over postcentral gyrus and cuneus during awakening period. This group expressed increased connectivity between motor cortex and cingulate during arousals unrelated to parasomnic events in the beta frequency band. They also showed lower connectivity between different portions of cingulum. In contrast, the greater connectivity was found between thalamus and some cortical areas, such as occipital cortex. Conclusion: Our findings suggest a complex alteration in falling asleep and arousal mechanisms at both subcortical and cortical levels in response to sleep deprivation. As this alteration is present also outside of slow wave sleep and/or parasomnic episodes we believe this could be a trait factor of DOA.http://www.sciencedirect.com/science/article/pii/S2590142723000265ParasomniasHigh density EEGFunctional brain imagingSlow wave sleepHdEEG and fMRI integrationDisorders of arousal |
| spellingShingle | E. Miletínová M. Piorecký V. Koudelka S. Jiříček D. Tomeček M. Brunovský J. Horáček J. Bušková Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study Sleep Medicine: X Parasomnias High density EEG Functional brain imaging Slow wave sleep HdEEG and fMRI integration Disorders of arousal |
| title | Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study |
| title_full | Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study |
| title_fullStr | Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study |
| title_full_unstemmed | Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study |
| title_short | Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study |
| title_sort | alterations of sleep initiation in nrem parasomnia after sleep deprivation a multimodal pilot study |
| topic | Parasomnias High density EEG Functional brain imaging Slow wave sleep HdEEG and fMRI integration Disorders of arousal |
| url | http://www.sciencedirect.com/science/article/pii/S2590142723000265 |
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