Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder
Abstract Background Major depressive disorder (MDD) is a common cause of disability and morbidity, affecting about 10% of the population worldwide. Subclinical depression (SD) can be understood as a precursor of MDD, and therefore provides an MDD risk indicator. The pathogenesis of MDD and SD in hum...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-04221-6 |
| _version_ | 1828735340560515072 |
|---|---|
| author | Lei Yang Chaoyang Jin Shouliang Qi Yueyang Teng Chen Li Yudong Yao Xiuhang Ruan Xinhua Wei |
| author_facet | Lei Yang Chaoyang Jin Shouliang Qi Yueyang Teng Chen Li Yudong Yao Xiuhang Ruan Xinhua Wei |
| author_sort | Lei Yang |
| collection | DOAJ |
| description | Abstract Background Major depressive disorder (MDD) is a common cause of disability and morbidity, affecting about 10% of the population worldwide. Subclinical depression (SD) can be understood as a precursor of MDD, and therefore provides an MDD risk indicator. The pathogenesis of MDD and SD in humans is still unclear, and the current diagnosis lacks accurate biomarkers and gold standards. Methods A total of 40 MDD, 34 SD, and 40 healthy control (HC) participants matched by age, gender, and education were included in this study. Resting-state functional magnetic resonance images (rs-fMRI) were used to analyze the functional connectivity (FC) of the posterior parietal thalamus (PPtha), which includes the lateral habenula, as the region of interest. Analysis of variance with the post hoc t-test test was performed to find significant differences in FC and clarify the variations in FC among the HC, SD, and MDD groups. Results Increased FC was observed between PPtha and the left inferior temporal gyrus (ITG) for MDD versus SD, and between PPtha and the right ITG for SD versus HC. Conversely, decreased FC was observed between PPtha and the right middle temporal gyrus (MTG) for MDD versus SD and MDD versus HC. The FC between PPtha and the middle frontal gyrus (MFG) in SD was higher than that in MDD and HC. Compared with the HC group, the FC of PPtha-ITG (left and right) increased in both the SD and MDD groups, PPtha-MTG (right) decreased in both the SD and MDD groups and PPtha-MFG (right) increased in the SD group and decreased in the MDD group. Conclusion Through analysis of FC measured by rs-fMRI, the altered FC between PPtha and several brain regions (right and left ITG, right MTG, and right MFG) has been identified in participants with SD and MDD. Different alterations in FC between PPtha and these regions were identified for patients with depression. These findings might provide insights into the potential pathophysiological mechanisms of SD and MDD, especially related to PPtha and the lateral habenula. |
| first_indexed | 2024-04-12T23:05:09Z |
| format | Article |
| id | doaj.art-da2e19ac248d44c184a613388bf4d305 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-12T23:05:09Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-da2e19ac248d44c184a613388bf4d3052022-12-22T03:12:57ZengBMCBMC Psychiatry1471-244X2022-09-0122111210.1186/s12888-022-04221-6Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorderLei Yang0Chaoyang Jin1Shouliang Qi2Yueyang Teng3Chen Li4Yudong Yao5Xiuhang Ruan6Xinhua Wei7College of Medicine and Biological Information Engineering, Northeastern UniversityCollege of Medicine and Biological Information Engineering, Northeastern UniversityCollege of Medicine and Biological Information Engineering, Northeastern UniversityCollege of Medicine and Biological Information Engineering, Northeastern UniversityCollege of Medicine and Biological Information Engineering, Northeastern UniversityDepartment of Electrical and Computer Engineering, Stevens Institute of TechnologyDepartment of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologyDepartment of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologyAbstract Background Major depressive disorder (MDD) is a common cause of disability and morbidity, affecting about 10% of the population worldwide. Subclinical depression (SD) can be understood as a precursor of MDD, and therefore provides an MDD risk indicator. The pathogenesis of MDD and SD in humans is still unclear, and the current diagnosis lacks accurate biomarkers and gold standards. Methods A total of 40 MDD, 34 SD, and 40 healthy control (HC) participants matched by age, gender, and education were included in this study. Resting-state functional magnetic resonance images (rs-fMRI) were used to analyze the functional connectivity (FC) of the posterior parietal thalamus (PPtha), which includes the lateral habenula, as the region of interest. Analysis of variance with the post hoc t-test test was performed to find significant differences in FC and clarify the variations in FC among the HC, SD, and MDD groups. Results Increased FC was observed between PPtha and the left inferior temporal gyrus (ITG) for MDD versus SD, and between PPtha and the right ITG for SD versus HC. Conversely, decreased FC was observed between PPtha and the right middle temporal gyrus (MTG) for MDD versus SD and MDD versus HC. The FC between PPtha and the middle frontal gyrus (MFG) in SD was higher than that in MDD and HC. Compared with the HC group, the FC of PPtha-ITG (left and right) increased in both the SD and MDD groups, PPtha-MTG (right) decreased in both the SD and MDD groups and PPtha-MFG (right) increased in the SD group and decreased in the MDD group. Conclusion Through analysis of FC measured by rs-fMRI, the altered FC between PPtha and several brain regions (right and left ITG, right MTG, and right MFG) has been identified in participants with SD and MDD. Different alterations in FC between PPtha and these regions were identified for patients with depression. These findings might provide insights into the potential pathophysiological mechanisms of SD and MDD, especially related to PPtha and the lateral habenula.https://doi.org/10.1186/s12888-022-04221-6Subclinical depressionMajor depressive disorderFunctional connectivityResting-state fMRILateral habenula |
| spellingShingle | Lei Yang Chaoyang Jin Shouliang Qi Yueyang Teng Chen Li Yudong Yao Xiuhang Ruan Xinhua Wei Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder BMC Psychiatry Subclinical depression Major depressive disorder Functional connectivity Resting-state fMRI Lateral habenula |
| title | Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder |
| title_full | Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder |
| title_fullStr | Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder |
| title_full_unstemmed | Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder |
| title_short | Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder |
| title_sort | alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder |
| topic | Subclinical depression Major depressive disorder Functional connectivity Resting-state fMRI Lateral habenula |
| url | https://doi.org/10.1186/s12888-022-04221-6 |
| work_keys_str_mv | AT leiyang alterationsoffunctionalconnectivityofthelateralhabenulainsubclinicaldepressionandmajordepressivedisorder AT chaoyangjin alterationsoffunctionalconnectivityofthelateralhabenulainsubclinicaldepressionandmajordepressivedisorder AT shouliangqi alterationsoffunctionalconnectivityofthelateralhabenulainsubclinicaldepressionandmajordepressivedisorder AT yueyangteng alterationsoffunctionalconnectivityofthelateralhabenulainsubclinicaldepressionandmajordepressivedisorder AT chenli alterationsoffunctionalconnectivityofthelateralhabenulainsubclinicaldepressionandmajordepressivedisorder AT yudongyao alterationsoffunctionalconnectivityofthelateralhabenulainsubclinicaldepressionandmajordepressivedisorder AT xiuhangruan alterationsoffunctionalconnectivityofthelateralhabenulainsubclinicaldepressionandmajordepressivedisorder AT xinhuawei alterationsoffunctionalconnectivityofthelateralhabenulainsubclinicaldepressionandmajordepressivedisorder |