Genomic and Phenotypic Characterization of Clostridium botulinum Isolates from an Infant Botulism Case Suggests Adaptation Signatures to the Gut

Genomic and Phenotypic Characterization of Clostridium botulinum Isolates from an Infant Botulism Case Suggests Adaptation Signatures to the Gut

ABSTRACT In early life, the immature human gut microbiota is prone to colonization by pathogens that are usually outcompeted by mature microbiota in the adult gut. Colonization and neurotoxin production by a vegetative Clostridium botulinum culture in the gut of an infant can lead to flaccid paralys...

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Bibliographic Details
Main Authors: François P. Douillard, Yağmur Derman, Cédric Woudstra, Katja Selby, Tommi Mäklin, Martin B. Dorner, Harri Saxén, Brigitte G. Dorner, Hannu Korkeala, Miia Lindström
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
Clostridium botulinum
botulism
ecology
genomics
Online Access:https://journals.asm.org/doi/10.1128/mbio.02384-21

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