Biological Distribution after Oral Administration of Radioiodine-Labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs, and/or MRPs

Biological Distribution after Oral Administration of Radioiodine-Labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs, and/or MRPs

We evaluated the whole-body distribution of orally-administered radioiodine-125 labeled acetaminophen (<sup>125</sup>I-AP) to estimate gastrointestinal absorption of anionic drugs. <sup>125</sup>I-AP was added to human embryonic kidney (HEK)293 and Flp293 cells expressing hum...

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Bibliographic Details
Main Authors: Kakeru Sato, Asuka Mizutani, Yuka Muranaka, Jianwei Yao, Masato Kobayashi, Kana Yamazaki, Ryuichi Nishii, Kodai Nishi, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
gastrointestinal absorption
anion drugs and medicines
<sup>125</sup>I-acetaminophen
oral administration
drug transporters
Online Access:https://www.mdpi.com/1999-4923/15/2/497

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