Population Pharmacokinetic Analysis and Dosing Optimization of Prophylactic Fluconazole in Japanese Patients with Hematological Malignancy

Population Pharmacokinetic Analysis and Dosing Optimization of Prophylactic Fluconazole in Japanese Patients with Hematological Malignancy

We conducted population pharmacokinetic (PPK) analysis and Monte Carlo simulations to determine the appropriate prophylactic dose of fluconazole to prevent invasive candidiasis in patients with hematological malignancies. Patients receiving chemotherapy or hematopoietic stem cell transplantation at...

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Bibliographic Details
Main Authors: Yasutaka Sakamoto, Hikaru Isono, Yuki Enoki, Kazuaki Taguchi, Takuya Miyazaki, Hiroyoshi Kunimoto, Hirofumi Koike, Maki Hagihara, Kenji Matsumoto, Hideaki Nakajima, Yukiko Sahashi, Kazuaki Matsumoto
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Journal of Fungi
Subjects:
fluconazole
prophylaxis
population pharmacokinetic analysis
hematological malignancy
Monte Carlo simulation
probability of target attainment
Online Access:https://www.mdpi.com/2309-608X/7/11/975

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