Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review
Natural-based biomaterials play an important role in developing new products for medical applications, primarily in cutaneous injuries. A large panel of biomaterials with antioxidant properties has revealed an advancement in supporting and expediting tissue regeneration. However, their low bioavaila...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/4/787 |
| _version_ | 1797606668205293568 |
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| author | Nur Izzah Md Fadilah Shou Jin Phang Nurkhuzaiah Kamaruzaman Atiqah Salleh Mazlan Zawani Arka Sanyal Manira Maarof Mh Busra Fauzi |
| author_facet | Nur Izzah Md Fadilah Shou Jin Phang Nurkhuzaiah Kamaruzaman Atiqah Salleh Mazlan Zawani Arka Sanyal Manira Maarof Mh Busra Fauzi |
| author_sort | Nur Izzah Md Fadilah |
| collection | DOAJ |
| description | Natural-based biomaterials play an important role in developing new products for medical applications, primarily in cutaneous injuries. A large panel of biomaterials with antioxidant properties has revealed an advancement in supporting and expediting tissue regeneration. However, their low bioavailability in preventing cellular oxidative stress through the delivery system limits their therapeutic activity at the injury site. The integration of antioxidant compounds in the implanted biomaterial should be able to maintain their antioxidant activity while facilitating skin tissue recovery. This review summarises the recent literature that reported the role of natural antioxidant-incorporated biomaterials in promoting skin wound healing and tissue regeneration, which is supported by evidence from in vitro, in vivo, and clinical studies. Antioxidant-based therapies for wound healing have shown promising evidence in numerous animal studies, even though clinical studies remain very limited. We also described the underlying mechanism of reactive oxygen species (ROS) generation and provided a comprehensive review of ROS-scavenging biomaterials found in the literature in the last six years. |
| first_indexed | 2024-03-11T05:18:24Z |
| format | Article |
| id | doaj.art-da329f2a2dca461797ad640f8d6cd9aa |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T05:18:24Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-da329f2a2dca461797ad640f8d6cd9aa2023-11-17T18:04:17ZengMDPI AGAntioxidants2076-39212023-03-0112478710.3390/antiox12040787Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical ReviewNur Izzah Md Fadilah0Shou Jin Phang1Nurkhuzaiah Kamaruzaman2Atiqah Salleh3Mazlan Zawani4Arka Sanyal5Manira Maarof6Mh Busra Fauzi7Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaDepartment of Biomedical Science, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, MalaysiaCentre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaCentre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaDepartment of Biotechnology, KIIT University, Bhubaneswar 751024, IndiaCentre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaCentre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaNatural-based biomaterials play an important role in developing new products for medical applications, primarily in cutaneous injuries. A large panel of biomaterials with antioxidant properties has revealed an advancement in supporting and expediting tissue regeneration. However, their low bioavailability in preventing cellular oxidative stress through the delivery system limits their therapeutic activity at the injury site. The integration of antioxidant compounds in the implanted biomaterial should be able to maintain their antioxidant activity while facilitating skin tissue recovery. This review summarises the recent literature that reported the role of natural antioxidant-incorporated biomaterials in promoting skin wound healing and tissue regeneration, which is supported by evidence from in vitro, in vivo, and clinical studies. Antioxidant-based therapies for wound healing have shown promising evidence in numerous animal studies, even though clinical studies remain very limited. We also described the underlying mechanism of reactive oxygen species (ROS) generation and provided a comprehensive review of ROS-scavenging biomaterials found in the literature in the last six years.https://www.mdpi.com/2076-3921/12/4/787antioxidantbiomaterialswound healingoxidative stressdelivery system |
| spellingShingle | Nur Izzah Md Fadilah Shou Jin Phang Nurkhuzaiah Kamaruzaman Atiqah Salleh Mazlan Zawani Arka Sanyal Manira Maarof Mh Busra Fauzi Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review Antioxidants antioxidant biomaterials wound healing oxidative stress delivery system |
| title | Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review |
| title_full | Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review |
| title_fullStr | Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review |
| title_full_unstemmed | Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review |
| title_short | Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review |
| title_sort | antioxidant biomaterials in cutaneous wound healing and tissue regeneration a critical review |
| topic | antioxidant biomaterials wound healing oxidative stress delivery system |
| url | https://www.mdpi.com/2076-3921/12/4/787 |
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