A case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue lymphoma
Abstract Background Collision tumors are composed of two distinct tumor components. Collision tumors composed of pancreatic ductal adenocarcinoma and malignant lymphoma occurring in the pancreas have not been previously described in the scientific literature. In this case report, we describe a uniqu...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-02981-3 |
| _version_ | 1797853817258115072 |
|---|---|
| author | Ryuji Hirai Ken-ichi Omae Mitsuko Yodoya Syunji Fujie Masayoshi Fujii Kazuma Iwata Kentaro Imanishi Eisuke Kurihara Kazuhiro Yoshida Masaru Jida Kazuyasu Kobayashi Yoshiaki Kanaya Syuichiro Maruyama |
| author_facet | Ryuji Hirai Ken-ichi Omae Mitsuko Yodoya Syunji Fujie Masayoshi Fujii Kazuma Iwata Kentaro Imanishi Eisuke Kurihara Kazuhiro Yoshida Masaru Jida Kazuyasu Kobayashi Yoshiaki Kanaya Syuichiro Maruyama |
| author_sort | Ryuji Hirai |
| collection | DOAJ |
| description | Abstract Background Collision tumors are composed of two distinct tumor components. Collision tumors composed of pancreatic ductal adenocarcinoma and malignant lymphoma occurring in the pancreas have not been previously described in the scientific literature. In this case report, we describe a unique patient with a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue (MALT) lymphoma occurring in the pancreas. Case presentation An 82-year-old woman presented to our hospital complaining of dizziness. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large lymphoid lesion spreading from the peri-pancreatic tissue heading to the hepatic hilar plate, involving the hepatoduodenal ligament and the entire duodenum, also showing a hard tumor in the pancreas head. We performed echo-guided needle biopsies for each tumor and diagnosed a collision tumor composed of pancreatic ductal adenocarcinoma and low-grade B cell lymphoma. The patient underwent pancreaticoduodenectomy. The resected specimen showed an elastic hard tumor, 90 × 75 mm in size, located in the pancreatic head, and a whitish-yellow hard tumor involving the lower bile duct, 31 mm in size, located in the center of the pancreatic head. Pathological and immunohistochemical examination proved that pancreatic ductal adenocarcinoma and MALT lymphoma originating from the peri-pancreatic head collided in the pancreatic head. Conclusions To best of our knowledge, this is the first report of a surgically resected collision tumor of pancreatic ductal adenocarcinoma and MALT lymphoma originating from the peri-pancreatic head. A needle biopsy is useful when inconsistent findings are observed on diagnostic CT and MRI of tumor lesions since there is the possibility of a collision tumor. |
| first_indexed | 2024-04-09T19:55:45Z |
| format | Article |
| id | doaj.art-da3348dd576246cfa93c59212cfd39f4 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-09T19:55:45Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-da3348dd576246cfa93c59212cfd39f42023-04-03T05:29:22ZengBMCWorld Journal of Surgical Oncology1477-78192023-03-0121111210.1186/s12957-023-02981-3A case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue lymphomaRyuji Hirai0Ken-ichi Omae1Mitsuko Yodoya2Syunji Fujie3Masayoshi Fujii4Kazuma Iwata5Kentaro Imanishi6Eisuke Kurihara7Kazuhiro Yoshida8Masaru Jida9Kazuyasu Kobayashi10Yoshiaki Kanaya11Syuichiro Maruyama12Department of Surgery, Himeji St. Mary’s HospitalDepartment of Radiology, Himeji St. Mary’s HospitalDepartment of Radiology, Himeji St. Mary’s HospitalDepartment of Radiology, Himeji St. Mary’s HospitalDepartment of Pathology, Himeji St. Mary’s HospitalDepartment of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama UniversityDepartment of Surgery, Himeji St. Mary’s HospitalDepartment of Surgery, Himeji St. Mary’s HospitalDepartment of Surgery, Himeji St. Mary’s HospitalDepartment of Surgery, Himeji St. Mary’s HospitalDepartment of Surgery, Himeji St. Mary’s HospitalDepartment of Surgery, Himeji St. Mary’s HospitalDepartment of Surgery, Himeji St. Mary’s HospitalAbstract Background Collision tumors are composed of two distinct tumor components. Collision tumors composed of pancreatic ductal adenocarcinoma and malignant lymphoma occurring in the pancreas have not been previously described in the scientific literature. In this case report, we describe a unique patient with a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue (MALT) lymphoma occurring in the pancreas. Case presentation An 82-year-old woman presented to our hospital complaining of dizziness. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large lymphoid lesion spreading from the peri-pancreatic tissue heading to the hepatic hilar plate, involving the hepatoduodenal ligament and the entire duodenum, also showing a hard tumor in the pancreas head. We performed echo-guided needle biopsies for each tumor and diagnosed a collision tumor composed of pancreatic ductal adenocarcinoma and low-grade B cell lymphoma. The patient underwent pancreaticoduodenectomy. The resected specimen showed an elastic hard tumor, 90 × 75 mm in size, located in the pancreatic head, and a whitish-yellow hard tumor involving the lower bile duct, 31 mm in size, located in the center of the pancreatic head. Pathological and immunohistochemical examination proved that pancreatic ductal adenocarcinoma and MALT lymphoma originating from the peri-pancreatic head collided in the pancreatic head. Conclusions To best of our knowledge, this is the first report of a surgically resected collision tumor of pancreatic ductal adenocarcinoma and MALT lymphoma originating from the peri-pancreatic head. A needle biopsy is useful when inconsistent findings are observed on diagnostic CT and MRI of tumor lesions since there is the possibility of a collision tumor.https://doi.org/10.1186/s12957-023-02981-3Collision tumorPancreatic cancerMALT lymphoma |
| spellingShingle | Ryuji Hirai Ken-ichi Omae Mitsuko Yodoya Syunji Fujie Masayoshi Fujii Kazuma Iwata Kentaro Imanishi Eisuke Kurihara Kazuhiro Yoshida Masaru Jida Kazuyasu Kobayashi Yoshiaki Kanaya Syuichiro Maruyama A case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue lymphoma World Journal of Surgical Oncology Collision tumor Pancreatic cancer MALT lymphoma |
| title | A case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue lymphoma |
| title_full | A case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue lymphoma |
| title_fullStr | A case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue lymphoma |
| title_full_unstemmed | A case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue lymphoma |
| title_short | A case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri-pancreatic mucosa-associated lymphoid tissue lymphoma |
| title_sort | case report of a collision tumor composed of pancreatic ductal adenocarcinoma and peri pancreatic mucosa associated lymphoid tissue lymphoma |
| topic | Collision tumor Pancreatic cancer MALT lymphoma |
| url | https://doi.org/10.1186/s12957-023-02981-3 |
| work_keys_str_mv | AT ryujihirai acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kenichiomae acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT mitsukoyodoya acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT syunjifujie acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT masayoshifujii acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kazumaiwata acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kentaroimanishi acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT eisukekurihara acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kazuhiroyoshida acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT masarujida acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kazuyasukobayashi acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT yoshiakikanaya acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT syuichiromaruyama acasereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT ryujihirai casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kenichiomae casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT mitsukoyodoya casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT syunjifujie casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT masayoshifujii casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kazumaiwata casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kentaroimanishi casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT eisukekurihara casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kazuhiroyoshida casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT masarujida casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT kazuyasukobayashi casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT yoshiakikanaya casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma AT syuichiromaruyama casereportofacollisiontumorcomposedofpancreaticductaladenocarcinomaandperipancreaticmucosaassociatedlymphoidtissuelymphoma |