The effect of membrane thickness on the membrane permeabilizing activity of the cyclic lipopeptide tolaasin II

The effect of membrane thickness on the membrane permeabilizing activity of the cyclic lipopeptide tolaasin II

Tolaasin II is an amphiphilic, membrane-active, cyclic lipopeptide produced by Pseudomonas tolaasii and is responsible for brown blotch disease in mushroom. To better understand the mode of action and membrane selectivity of tolaasin II and related lipopeptides, its permeabilizing effect on liposome...

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Bibliographic Details
Main Authors: Jessica Steigenberger, Catherine Mergen, Vic De Roo, Niels Geudens, José C. Martins, Heiko Heerklotz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
cyclic lipopeptides
tolaasin II
equi-activity analysis
membrane thickness
packing mismatch
membrane stability
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1064742/full

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