Clinical Effectiveness of Continuous Infusion Flucloxacillin in the Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting in a UK Hospital: A Service Evaluation
The availability of stability data for the use of continuous intravenous flucloxacillin in an elastomeric device has enabled the treatment of serious Methicillin Sensitive <i>Staphylococcus aureus</i> (MSSA) in the outpatient parenteral antimicrobial therapy (OPAT) setting. This service...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/13/2/153 |
| _version_ | 1797299121236738048 |
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| author | Annette Margaret Clarkson Susan Snape |
| author_facet | Annette Margaret Clarkson Susan Snape |
| author_sort | Annette Margaret Clarkson |
| collection | DOAJ |
| description | The availability of stability data for the use of continuous intravenous flucloxacillin in an elastomeric device has enabled the treatment of serious Methicillin Sensitive <i>Staphylococcus aureus</i> (MSSA) in the outpatient parenteral antimicrobial therapy (OPAT) setting. This service review aimed to evaluate current standard of care to establish the clinical effectiveness and complication rates associated with its use since its introduction at our institution. A retrospective review of clinical outcomes and adverse events/complications, was undertaken for all patients who received continuous infusion flucloxacillin for complicated MSSA infection between January 2019 and July 2022 via our OPAT service. Thirty-nine patients were included. An OPAT treatment outcome of ‘Treatment aim attained uncomplicated’ was achieved in 29/39 (74%) patients. Two patients had an OPAT treatment outcome of treatment aim not attained, both of which required unexpected hospital re-admission. An adverse event/complication occurred in 8 patients. There were two relapses in the 12-month follow-up period. Our review supports the assertion that continuous infusion flucloxacillin is clinically effective and well tolerated for the treatment of complicated MSSA infection in the OPAT setting. |
| first_indexed | 2024-03-07T22:44:59Z |
| format | Article |
| id | doaj.art-da343191bf0943a4b162c4985a69014a |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-07T22:44:59Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-da343191bf0943a4b162c4985a69014a2024-02-23T15:05:04ZengMDPI AGAntibiotics2079-63822024-02-0113215310.3390/antibiotics13020153Clinical Effectiveness of Continuous Infusion Flucloxacillin in the Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting in a UK Hospital: A Service EvaluationAnnette Margaret Clarkson0Susan Snape1Pharmacy Department, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UKMicrobiology Department, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UKThe availability of stability data for the use of continuous intravenous flucloxacillin in an elastomeric device has enabled the treatment of serious Methicillin Sensitive <i>Staphylococcus aureus</i> (MSSA) in the outpatient parenteral antimicrobial therapy (OPAT) setting. This service review aimed to evaluate current standard of care to establish the clinical effectiveness and complication rates associated with its use since its introduction at our institution. A retrospective review of clinical outcomes and adverse events/complications, was undertaken for all patients who received continuous infusion flucloxacillin for complicated MSSA infection between January 2019 and July 2022 via our OPAT service. Thirty-nine patients were included. An OPAT treatment outcome of ‘Treatment aim attained uncomplicated’ was achieved in 29/39 (74%) patients. Two patients had an OPAT treatment outcome of treatment aim not attained, both of which required unexpected hospital re-admission. An adverse event/complication occurred in 8 patients. There were two relapses in the 12-month follow-up period. Our review supports the assertion that continuous infusion flucloxacillin is clinically effective and well tolerated for the treatment of complicated MSSA infection in the OPAT setting.https://www.mdpi.com/2079-6382/13/2/153flucloxacillinOPATcontinuous infusion<i>Staphylococcus aureus</i> bacteraemiaMSSAelastomeric device |
| spellingShingle | Annette Margaret Clarkson Susan Snape Clinical Effectiveness of Continuous Infusion Flucloxacillin in the Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting in a UK Hospital: A Service Evaluation Antibiotics flucloxacillin OPAT continuous infusion <i>Staphylococcus aureus</i> bacteraemia MSSA elastomeric device |
| title | Clinical Effectiveness of Continuous Infusion Flucloxacillin in the Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting in a UK Hospital: A Service Evaluation |
| title_full | Clinical Effectiveness of Continuous Infusion Flucloxacillin in the Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting in a UK Hospital: A Service Evaluation |
| title_fullStr | Clinical Effectiveness of Continuous Infusion Flucloxacillin in the Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting in a UK Hospital: A Service Evaluation |
| title_full_unstemmed | Clinical Effectiveness of Continuous Infusion Flucloxacillin in the Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting in a UK Hospital: A Service Evaluation |
| title_short | Clinical Effectiveness of Continuous Infusion Flucloxacillin in the Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting in a UK Hospital: A Service Evaluation |
| title_sort | clinical effectiveness of continuous infusion flucloxacillin in the outpatient parenteral antimicrobial therapy opat setting in a uk hospital a service evaluation |
| topic | flucloxacillin OPAT continuous infusion <i>Staphylococcus aureus</i> bacteraemia MSSA elastomeric device |
| url | https://www.mdpi.com/2079-6382/13/2/153 |
| work_keys_str_mv | AT annettemargaretclarkson clinicaleffectivenessofcontinuousinfusionflucloxacillinintheoutpatientparenteralantimicrobialtherapyopatsettinginaukhospitalaserviceevaluation AT susansnape clinicaleffectivenessofcontinuousinfusionflucloxacillinintheoutpatientparenteralantimicrobialtherapyopatsettinginaukhospitalaserviceevaluation |