4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis

4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis

Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6...

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Bibliographic Details
Main Authors: Antoniana U. Krettli, Lucas S. Madureira, Lucia M. X. Lopes, Tito da Silva, Marcos D. P. Pereira, Julio Zukerman-Schpector
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Molecules
Subjects:
Holostylis reniformis
Aristolochiaceae
sesquiterpene
4,5-seco-guaiane
megastigmane
Online Access:http://www.mdpi.com/1420-3049/17/12/14046
Description
Summary:Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxy-ethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol and sitosterol-3-O-β-D-glucopyranoside. The structures of these compounds were determined by spectroscopic analyses and B3LYP/STO-3G** theoretical studies.
ISSN:1420-3049

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