To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL)
Hodgkin lymphoma differs from anaplastic largecell lymphoma (ALCL) (≪Hodgkin-like≫ variant) by more frequent early stage diseases revealing (46%), mediastinal lymph nodes involvement (69%), softtissue components absence, small number of cases with more than one extranodal organ involvement (15%), AL...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-11-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/736 |
| _version_ | 1797855504827940864 |
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| author | A. A. Semenova I. V. Poddubnay N. A. Probatova E. A. Osmanov E. N. Sorokin |
| author_facet | A. A. Semenova I. V. Poddubnay N. A. Probatova E. A. Osmanov E. N. Sorokin |
| author_sort | A. A. Semenova |
| collection | DOAJ |
| description | Hodgkin lymphoma differs from anaplastic largecell lymphoma (ALCL) (≪Hodgkin-like≫ variant) by more frequent early stage diseases revealing (46%), mediastinal lymph nodes involvement (69%), softtissue components absence, small number of cases with more than one extranodal organ involvement (15%), ALK-protein absence (100%) and tumor cell B-immunophenotype (PAX 5+). Morphological features: the expressed pironinophilia in tumor cells cytoplasm by Broshe staining in systemic ALCL (T-/0 phenotype), that is rare observed in Hodgkin lymphoma; large tumor cells in systemic ALCL (_-/0 phenotype) have more polymorphic nucleuses with small nucleoluses in comparison with more spherical cells with large nucleoluses in Hodgkin lymphona; intrasinus growth observed almost in a half of cases in systemic ALCL (T-/0 phenotype) does not revealed in Hodgkin lymphoma; tumor tissue fibrosis is a rare observation in systemic ALCL (T-/0 phenotype), while fibrosis and capsule sclerosis are frequent morphological signs in Hodgkin lymphoma. |
| first_indexed | 2024-04-09T20:23:40Z |
| format | Article |
| id | doaj.art-da34aa6f39974131b9c037a37a349c79 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:23:40Z |
| publishDate | 2022-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-da34aa6f39974131b9c037a37a349c792023-03-30T20:15:15ZrusABV-pressОнкогематология1818-83462413-40232022-11-0102222710.17650/1818-8346-2009-0-2-22-27614To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL)A. A. Semenova0I. V. Poddubnay1N. A. Probatova2E. A. Osmanov3E. N. Sorokin4Russian Academy for Postgraduate Medical EducationRussian Academy for Postgraduate Medical EducationN. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesN. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesN. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesHodgkin lymphoma differs from anaplastic largecell lymphoma (ALCL) (≪Hodgkin-like≫ variant) by more frequent early stage diseases revealing (46%), mediastinal lymph nodes involvement (69%), softtissue components absence, small number of cases with more than one extranodal organ involvement (15%), ALK-protein absence (100%) and tumor cell B-immunophenotype (PAX 5+). Morphological features: the expressed pironinophilia in tumor cells cytoplasm by Broshe staining in systemic ALCL (T-/0 phenotype), that is rare observed in Hodgkin lymphoma; large tumor cells in systemic ALCL (_-/0 phenotype) have more polymorphic nucleuses with small nucleoluses in comparison with more spherical cells with large nucleoluses in Hodgkin lymphona; intrasinus growth observed almost in a half of cases in systemic ALCL (T-/0 phenotype) does not revealed in Hodgkin lymphoma; tumor tissue fibrosis is a rare observation in systemic ALCL (T-/0 phenotype), while fibrosis and capsule sclerosis are frequent morphological signs in Hodgkin lymphoma.https://oncohematology.abvpress.ru/ongm/article/view/736анапластическая крупноклеточная лимфомалимфома ходжкинадиагностические критериииммунофенотипические особенностиклиническое течениепрогностические группы |
| spellingShingle | A. A. Semenova I. V. Poddubnay N. A. Probatova E. A. Osmanov E. N. Sorokin To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL) Онкогематология анапластическая крупноклеточная лимфома лимфома ходжкина диагностические критерии иммунофенотипические особенности клиническое течение прогностические группы |
| title | To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL) |
| title_full | To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL) |
| title_fullStr | To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL) |
| title_full_unstemmed | To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL) |
| title_short | To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL) |
| title_sort | to the issue of differential diagnosis of hodgkin lymphoma and t phenotype anaplastic large cell lymphoma alcl |
| topic | анапластическая крупноклеточная лимфома лимфома ходжкина диагностические критерии иммунофенотипические особенности клиническое течение прогностические группы |
| url | https://oncohematology.abvpress.ru/ongm/article/view/736 |
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