Synthesis, Neuroprotection, and Antioxidant Activity of 1,1′-Biphenylnitrones as α-Phenyl-<i>N-tert</i>-butylnitrone Analogues in In Vitro Ischemia Models

Synthesis, Neuroprotection, and Antioxidant Activity of 1,1′-Biphenylnitrones as α-Phenyl-<i>N-tert</i>-butylnitrone Analogues in In Vitro Ischemia Models

Herein, we report the neuroprotective and antioxidant activity of 1,1′-biphenyl nitrones (<b>BPNs</b>) <b>1</b>–<b>5</b> as α-phenyl-<i>N</i>-<i>tert</i>-butylnitrone analogues prepared from commercially available [1,1′-biphenyl]-4-carbalde...

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Bibliographic Details
Main Authors: Beatriz Chamorro, David García-Vieira, Daniel Diez-Iriepa, Estíbaliz Garagarza, Mourad Chioua, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
antioxidants
1,1′-biphenyl nitrones
free radical scavengers
neuroprotection
oligomycin A/rotenone
oxygen-glucose-deprivation
Online Access:https://www.mdpi.com/1420-3049/26/4/1127

Internet

https://www.mdpi.com/1420-3049/26/4/1127

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