Exploiting the Zonulin Mouse Model to Establish the Role of Primary Impaired Gut Barrier Function on Microbiota Composition and Immune Profiles

Exploiting the Zonulin Mouse Model to Establish the Role of Primary Impaired Gut Barrier Function on Microbiota Composition and Immune Profiles

The balanced interplay between epithelial barrier, immune system, and microbiota maintains gut homeostasis, while disruption of this interplay may lead to inflammation. Paracellular permeability is governed by intercellular tight-junctions (TJs). Zonulin is, to date, the only known physiological reg...

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Bibliographic Details
Main Authors: Alba Miranda-Ribera, Maria Ennamorati, Gloria Serena, Murat Cetinbas, Jinggang Lan, Ruslan I. Sadreyev, Nitya Jain, Alessio Fasano, Maria Fiorentino
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
gut permeability
microbial products trafficking
tight-junctions
zonulin transgenic mouse
microbiota
dysbiosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02233/full

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