Antiradical Activity of Beetroot (<i>Beta vulgaris</i> L.) Betalains
Flavonoids, phenolic acids, and anthocyanidins are widely studied polyphenolics owing to their antiradical activity. Recently, beetroot dyes have drawn an attention as possible radical scavengers, but scant information can be found on this topic. In this study selected compounds were investigated us...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/9/2439 |
| _version_ | 1797536745202384896 |
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| author | Maciej Spiegel Andrzej Gamian Zbigniew Sroka |
| author_facet | Maciej Spiegel Andrzej Gamian Zbigniew Sroka |
| author_sort | Maciej Spiegel |
| collection | DOAJ |
| description | Flavonoids, phenolic acids, and anthocyanidins are widely studied polyphenolics owing to their antiradical activity. Recently, beetroot dyes have drawn an attention as possible radical scavengers, but scant information can be found on this topic. In this study selected compounds were investigated using computational chemistry methods. Implicit water at physiological pH was chosen as the environment of interest. Betalains’ dissociation process and electronic structure were examined, as well as the reactivity in six pathways against some common radicals, such as hydroxyl, hydroperoxide, superoxide, and nitric oxide. The study showed that all carboxyl groups are dissociated in the given conditions. The dissociation process impacts the electronic structure, which has consequences for the overall activity. Highly stabilized conjugated structures favor the electron–accepting type of scavenging reactions, primarily by a radical adduct formation mechanism. Betanidin and indicaxanthin were found to be the most promising of the compounds studied. Nevertheless, the study established the role of betalains as powerful antiradical dietary agents. |
| first_indexed | 2024-03-10T12:05:08Z |
| format | Article |
| id | doaj.art-da36db2bbde84d3f9cb073efbeb316d4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:05:08Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-da36db2bbde84d3f9cb073efbeb316d42023-11-21T16:40:13ZengMDPI AGMolecules1420-30492021-04-01269243910.3390/molecules26092439Antiradical Activity of Beetroot (<i>Beta vulgaris</i> L.) BetalainsMaciej Spiegel0Andrzej Gamian1Zbigniew Sroka2Department of Pharmacognosy and Herbal Medicines, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandLudwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, PolandDepartment of Pharmacognosy and Herbal Medicines, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandFlavonoids, phenolic acids, and anthocyanidins are widely studied polyphenolics owing to their antiradical activity. Recently, beetroot dyes have drawn an attention as possible radical scavengers, but scant information can be found on this topic. In this study selected compounds were investigated using computational chemistry methods. Implicit water at physiological pH was chosen as the environment of interest. Betalains’ dissociation process and electronic structure were examined, as well as the reactivity in six pathways against some common radicals, such as hydroxyl, hydroperoxide, superoxide, and nitric oxide. The study showed that all carboxyl groups are dissociated in the given conditions. The dissociation process impacts the electronic structure, which has consequences for the overall activity. Highly stabilized conjugated structures favor the electron–accepting type of scavenging reactions, primarily by a radical adduct formation mechanism. Betanidin and indicaxanthin were found to be the most promising of the compounds studied. Nevertheless, the study established the role of betalains as powerful antiradical dietary agents.https://www.mdpi.com/1420-3049/26/9/2439antioxidantsdensity functional theorybetalainsreactive oxygen speciesbeetrootphytochemicals |
| spellingShingle | Maciej Spiegel Andrzej Gamian Zbigniew Sroka Antiradical Activity of Beetroot (<i>Beta vulgaris</i> L.) Betalains Molecules antioxidants density functional theory betalains reactive oxygen species beetroot phytochemicals |
| title | Antiradical Activity of Beetroot (<i>Beta vulgaris</i> L.) Betalains |
| title_full | Antiradical Activity of Beetroot (<i>Beta vulgaris</i> L.) Betalains |
| title_fullStr | Antiradical Activity of Beetroot (<i>Beta vulgaris</i> L.) Betalains |
| title_full_unstemmed | Antiradical Activity of Beetroot (<i>Beta vulgaris</i> L.) Betalains |
| title_short | Antiradical Activity of Beetroot (<i>Beta vulgaris</i> L.) Betalains |
| title_sort | antiradical activity of beetroot i beta vulgaris i l betalains |
| topic | antioxidants density functional theory betalains reactive oxygen species beetroot phytochemicals |
| url | https://www.mdpi.com/1420-3049/26/9/2439 |
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