INFLUENCE OF MELATONIN AND GAS TRANSMITTERS ON THE DEVELOPMENT OF OXIDATIVE DAMAGE INDUCED BY LIPOPOLISACCHARIDE ADMINISTRATION
Objective: to study the effect of melatonin and gas transmitters on the development of oxidative damage induced by triple injection of lipopolysaccharide (LPS). Material and methods. Simulation of oxidative stress was carried out by administering LPS for three days at a dose of 5 mg/kg, and its c...
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| Format: | Article |
| Language: | Belarusian |
| Published: |
Grodno State Medical University
2019-03-01
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| Series: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| Subjects: | |
| Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2363 |
| Summary: | Objective: to study the effect of melatonin and gas transmitters on the development of oxidative damage induced by
triple injection of lipopolysaccharide (LPS).
Material and methods. Simulation of oxidative stress was carried out by administering LPS for three days at a dose
of 5 mg/kg, and its correction was performed using melatonin, L-arginine and sodium hydrosulfide with subsequent
determination of lipid peroxidation and antioxidant potential in the tissues of the heart, liver, kidneys and the lungs.
Results. Injection of melatonin, L-arginine or donor of hydrogen sulfide (NaHS) 12 hours after the last injection of
LPS, lead to a decrease in lipid peroxidation activity (diene and triene conjugates, malonic dialdehyde) and increase
in the activity of the antioxidant defense system (catalase, reduced glutathione, α-tocopherol, retinol).
Conclusions. Melatonin reduces the activity of free radical processes and increases the level of antioxidant potential
in the studied tissues, while L-arginine and NaHS do not enhance this effect of melatonin. |
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| ISSN: | 2221-8785 2413-0109 |