Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies
Objectives Anxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Fiv...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/5/e068725.full |
| _version_ | 1827176729123225600 |
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| author | Luís Taborda-Barata Joana Carvalho Diana Bordalo Cristina Jácome Ana Margarida Pereira Rute Almeida Manuel Ferreira-Magalhaes Cláudia Chaves Loureiro Cristina Lopes Carmelita Ribeiro Carlos Lozoya Natacha Santos Maria João Vasconcelos Pedro Morais Silva Raquel Câmara Rosário Ferreira Maria José Calix Carlos Nunes Joao A Fonseca Sara Fernandes Rosália Páscoa Luís Monteiro Carmen Vidal Darío Antolín-Amérigo Mafalda Simões Cunha Rita Amaral Magna Alves-Correia Diana Pinto Francisca Cardia Tania Monteiro Ferreira Eurico Silva Cristina Guimarães Sofia da Silva Maria Luís Marques Ana Morete Cláudia Vieira Adelaide Alves José Varanda Marques Bruno Reis Rosário Monteiro Margarida Cepa Bruno Valentim Daniela Sousa Coelho Patrícia Meireles Margarida Abreu Aguiar Ana Rita Mourão |
| author_facet | Luís Taborda-Barata Joana Carvalho Diana Bordalo Cristina Jácome Ana Margarida Pereira Rute Almeida Manuel Ferreira-Magalhaes Cláudia Chaves Loureiro Cristina Lopes Carmelita Ribeiro Carlos Lozoya Natacha Santos Maria João Vasconcelos Pedro Morais Silva Raquel Câmara Rosário Ferreira Maria José Calix Carlos Nunes Joao A Fonseca Sara Fernandes Rosália Páscoa Luís Monteiro Carmen Vidal Darío Antolín-Amérigo Mafalda Simões Cunha Rita Amaral Magna Alves-Correia Diana Pinto Francisca Cardia Tania Monteiro Ferreira Eurico Silva Cristina Guimarães Sofia da Silva Maria Luís Marques Ana Morete Cláudia Vieira Adelaide Alves José Varanda Marques Bruno Reis Rosário Monteiro Margarida Cepa Bruno Valentim Daniela Sousa Coelho Patrícia Meireles Margarida Abreu Aguiar Ana Rita Mourão |
| author_sort | Luís Taborda-Barata |
| collection | DOAJ |
| description | Objectives Anxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Five Dimension Questionnaire (EQ-5D); the level of agreement between these questionnaires, and the factors associated with these symptoms.Methods This is a secondary analysis of the INSPIRERS studies. A total of 614 adolescents and adults with persistent asthma (32.6±16.9 years, 64.7% female) were recruited from 30 primary care centres and 32 allergy, pulmonology and paediatric clinics. Demographic and clinical characteristics, HADS and EQ-5D were collected. A score ≥8 on Hospital Anxiety and Depression Scale-Anxiety/Hospital Anxiety and Depression Scale-Depression or a positive answer to EQ-5D item 5 indicated the presence of these symptoms. Agreement was determined by Cohen’s kappa. Two multivariable logistic regressions were built.Results According to HADS, 36% of the participants had symptoms of anxiety and 12% of depression. According to EQ-5D, 36% of the participants had anxiety/depression. The agreement between questionnaires in identifying anxiety/depression was moderate (k=0.55, 95% CI 0.48 to 0.62). Late asthma diagnosis, comorbidities and female gender were predictors of anxiety/depression, while better asthma control, health-related quality of life and perception of health were associated with lower odds for anxiety/depression.Conclusion At least 1/3 of the patients with persistent asthma experience symptoms of anxiety/depression, showing the relevance of screening these disorders in patients with asthma. EQ-5D and HADS questionnaires showed a moderate agreement in the identification of anxiety/depression symptoms. The identified associated factors need to be further investigated in long-term studies. |
| first_indexed | 2024-04-09T14:14:38Z |
| format | Article |
| id | doaj.art-da374d033cbc4759946769f83815f87c |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-03-21T04:31:58Z |
| publishDate | 2023-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-da374d033cbc4759946769f83815f87c2024-07-27T02:50:10ZengBMJ Publishing GroupBMJ Open2044-60552023-05-0113510.1136/bmjopen-2022-068725Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studiesLuís Taborda-Barata0Joana Carvalho1Diana Bordalo2Cristina Jácome3Ana Margarida Pereira4Rute Almeida5Manuel Ferreira-Magalhaes6Cláudia Chaves Loureiro7Cristina Lopes8Carmelita Ribeiro9Carlos Lozoya10Natacha Santos11Maria João Vasconcelos12Pedro Morais Silva13Raquel Câmara14Rosário Ferreira15Maria José Calix16Carlos Nunes17Joao A Fonseca18Sara Fernandes19Rosália Páscoa20Luís Monteiro21Carmen Vidal22Darío Antolín-Amérigo23Mafalda Simões Cunha24Rita Amaral25Magna Alves-Correia26Diana Pinto27Francisca Cardia28Tania Monteiro Ferreira29Eurico Silva30Cristina Guimarães31Sofia da Silva32Maria Luís Marques33Ana Morete34Cláudia Vieira35Adelaide Alves36José Varanda Marques37Bruno Reis38Rosário Monteiro39Margarida Cepa40Bruno Valentim41Daniela Sousa Coelho42Patrícia Meireles43Margarida Abreu Aguiar44Ana Rita Mourão45Department of Allergy & Clinical Immunology, Cova da Beira University Hospital Centre, Covilhã, PortugalServiço de Pediatria, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos, Matosinhos, PortugalServiço de Pediatria, Unidade Hospitalar de Famalicão, Centro Hospitalar do Médio Ave, Vila Nova de Famalicão, PortugalCINTESIS@RISE, MEDCIDS, Faculty of Medicine of the University of Porto, Porto, PortugalCenter for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, PortugalCINTESIS@RISE, MEDCIDS, Faculty of Medicine of the University of Porto, Porto, PortugalCINTESIS@RISE, MEDCIDS, Faculty of Medicine of the University of Porto, Porto, PortugalPulmonology Department, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, PortugalBasic and Clinic Immunology, Faculty of Medicine of the University of Porto, Porto, PortugalServiço de Imunoalergologia, Hospital Universitário de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, PortugalAllergy, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Castelo Branco, PortugalServiço de Imunoalergologia, Centro Hospitalar Universitário do Algarve, Portimão, PortugalServiço de Imunoalergologia, Centro Hospitalar Universitário de São João, Porto, PortugalImmuno-Allergology, Grupo HPA Saúde, Portimao, PortugalServiço de Pneumologia, Hospital Nossa Senhora do Rosário, Centro Hospitalar Barreiro Montijo, Barreiro, PortugalDepartamento de Pediatria, Hospital de Santa Maria, Centro Hospitalar de Lisboa Norte, Lisboa, PortugalServiço de Pediatria, Hospital de São Teotónio, Centro Hospitalar Tondela Viseu, Viseu, PortugalCentro de Imunoalergologia do Algarve, Portimão, PortugalAllergy Unit, Instituto and Hospital CUF, Porto, PortugalUnidade de Saúde Familiar Bracara Augusta, ACES Cávado I, Braga, PortugalCenter for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, PortugalCenter for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, PortugalServicio de Alergia, Complejo Hospitalario Universitario de Santiago, Santiago de Compostella, SpainServicio de Alergia, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, SpainCenter for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, PortugalAllergy Unit, Instituto and Hospital CUF, Porto, PortugalCenter for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, PortugalServiço de Pediatria, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Porto, PortugalUnidade de Saúde Familiar Terras de Azurara, Agrupamento de Centros de Saúde Dão Lafões, Mangualde, PortugalUnidade de Saúde Familiar Progresso e Saúde, Agrupamento de Centros de Saúde Baixo Mondego, Tocha, PortugalUnidade de Saúde Familiar João Semana, Agrupamento de Centros de Saúde de Baixo Vouga, Ovar, PortugalUnidade de Cuidados de Saúde Personalizados Norte (Arnaldo Sampaio), Agrupamento de Centros de Saúde Pinhal Litoral, Monte Redondo, PortugalUnidade de Saúde Familiar Cuidarte, Unidade Local de Saúde do Alto Minho, Portuzelo, PortugalServiço de Imunoalergologia, Hospital da Senhora da Oliveira, Guimarães, Guimaraes, PortugalAllergy Unit, Instituto and Hospital CUF, Porto, PortugalUnidade de Saúde Familiar Corgo, Agrupamento de Centros de Saúde Douro I - Marão e Douro Norte, Vila Real, PortugalServiço de Pneumologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, PortugalUnidade de Saúde Familiar Viseu-Cidade, Agrupamento de Centros de Saúde do Dão Lafões, Viseu, PortugalUnidade de Cuidados Saúde Personalizados Sicó, Agrupamento de Centros de Saúde Pinhal Litoral, Leiria, PortugalCINTESIS@RISE, MEDCIDS, Faculty of Medicine of the University of Porto, Porto, PortugalUnidade de Saúde Familiar Marquês, ACES Pinhal Litoral, Pombal, PortugalUnidade de Saúde Familiar Condeixa, ACES Baixo Mondego, Condeixa-a-Nova, PortugalUnidade de Cuidados de Saúde Personalizados de Amarante, ACES Tâmega I - Baixo Tâmega, Amarante, PortugalUnidade de Saúde Familiar Almedina, ACES Douro II - Douro Sul, Lamego, PortugalUnidade de Saúde Familiar Valongo, ACES Grande Porto III - Maia / Valongo, Valongo, PortugalUnidade de Saúde Familiar Canelas, ACES Grande Porto VIII - Espinho / Gaia, Vila Nova de Gaia, PortugalObjectives Anxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Five Dimension Questionnaire (EQ-5D); the level of agreement between these questionnaires, and the factors associated with these symptoms.Methods This is a secondary analysis of the INSPIRERS studies. A total of 614 adolescents and adults with persistent asthma (32.6±16.9 years, 64.7% female) were recruited from 30 primary care centres and 32 allergy, pulmonology and paediatric clinics. Demographic and clinical characteristics, HADS and EQ-5D were collected. A score ≥8 on Hospital Anxiety and Depression Scale-Anxiety/Hospital Anxiety and Depression Scale-Depression or a positive answer to EQ-5D item 5 indicated the presence of these symptoms. Agreement was determined by Cohen’s kappa. Two multivariable logistic regressions were built.Results According to HADS, 36% of the participants had symptoms of anxiety and 12% of depression. According to EQ-5D, 36% of the participants had anxiety/depression. The agreement between questionnaires in identifying anxiety/depression was moderate (k=0.55, 95% CI 0.48 to 0.62). Late asthma diagnosis, comorbidities and female gender were predictors of anxiety/depression, while better asthma control, health-related quality of life and perception of health were associated with lower odds for anxiety/depression.Conclusion At least 1/3 of the patients with persistent asthma experience symptoms of anxiety/depression, showing the relevance of screening these disorders in patients with asthma. EQ-5D and HADS questionnaires showed a moderate agreement in the identification of anxiety/depression symptoms. The identified associated factors need to be further investigated in long-term studies.https://bmjopen.bmj.com/content/13/5/e068725.full |
| spellingShingle | Luís Taborda-Barata Joana Carvalho Diana Bordalo Cristina Jácome Ana Margarida Pereira Rute Almeida Manuel Ferreira-Magalhaes Cláudia Chaves Loureiro Cristina Lopes Carmelita Ribeiro Carlos Lozoya Natacha Santos Maria João Vasconcelos Pedro Morais Silva Raquel Câmara Rosário Ferreira Maria José Calix Carlos Nunes Joao A Fonseca Sara Fernandes Rosália Páscoa Luís Monteiro Carmen Vidal Darío Antolín-Amérigo Mafalda Simões Cunha Rita Amaral Magna Alves-Correia Diana Pinto Francisca Cardia Tania Monteiro Ferreira Eurico Silva Cristina Guimarães Sofia da Silva Maria Luís Marques Ana Morete Cláudia Vieira Adelaide Alves José Varanda Marques Bruno Reis Rosário Monteiro Margarida Cepa Bruno Valentim Daniela Sousa Coelho Patrícia Meireles Margarida Abreu Aguiar Ana Rita Mourão Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies BMJ Open |
| title | Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies |
| title_full | Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies |
| title_fullStr | Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies |
| title_full_unstemmed | Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies |
| title_short | Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies |
| title_sort | symptoms of anxiety and depression in patients with persistent asthma a cross sectional analysis of the inspirers studies |
| url | https://bmjopen.bmj.com/content/13/5/e068725.full |
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