Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia
Abstract Background: Sarcopenia is an age-related skeletal muscle disorder that involves a loss of muscle mass or strength and physiological function. Skeletal muscle deteriorates in both quantity and quality. The endocrine system is an important regulator of muscle metabolism. Therefore, we aimed t...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-03491-9 |
| _version_ | 1811186911993135104 |
|---|---|
| author | Mengting Yin He Zhang Qianhui Liu Fei Ding Lisha Hou Yiping Deng Tao Cui Yixian Han Yijun Chen Chen Huang Jirong Yue Yong He |
| author_facet | Mengting Yin He Zhang Qianhui Liu Fei Ding Lisha Hou Yiping Deng Tao Cui Yixian Han Yijun Chen Chen Huang Jirong Yue Yong He |
| author_sort | Mengting Yin |
| collection | DOAJ |
| description | Abstract Background: Sarcopenia is an age-related skeletal muscle disorder that involves a loss of muscle mass or strength and physiological function. Skeletal muscle deteriorates in both quantity and quality. The endocrine system is an important regulator of muscle metabolism. Therefore, we aimed to explore the relationship between biochemical markers and muscle mass in sarcopenia. Methods: We used the AWGS 2014 as the diagnostic criteria for sarcopenia, considering both the loss in muscle mass, muscle strength and physical performance. A total of 2837 elderly female participants over 50 years of age from the West China Health and Aging Trend (WCHAT) study were included. Insulin, glucose, 25(OH)VD, procalcitonin, alanine aminotransferase, aspartate aminotransferase, total protein, prealbumin, albumin, thyroid-stimulating hormone, free triiodothyronine, free tetraiodothyronine, triglycerides, cholesterol, high-density lipoprotein, very low-density lipoprotein, cortisol, and follicle-stimulating hormone were measured. Based on the findings of univariate analysis, multivariate regression and receiver operating characteristic (ROC) curves were established. Results: Participants with sarcopenia had significantly lower free triiodothyronine, insulin, total protein, albumin, prealbumin, albumin/prealbumin ratio (A/G), alanine aminotransferase, triglycerides, and very low-density lipoprotein concentrations (P < 0.05). Compared with those without sarcopenia, those with sarcopenia had significantly higher free tetraiodothyronine, cortisol, follicle-stimulating hormone (FSH), aspartate aminotransferase/alanine aminotransferase ratio (AST/ALT), and high-density lipoprotein concentrations (P < 0.05). Insulin (OR = 0.854), FSH (OR = 1.016), and the AST/ALT ratio (OR = 1.819) were independent risk factors for low muscle mass (P < 0.001). The AUC of insulin was the highest, followed by the AST/ALT ratio and FSH (0.691, 0.671, and 0.634, respectively), and the AUC of the mixture of the above three reached 0.736. Conclusion: In this cross-sectional study of elderly Chinese females aged over 50 years from the WCHAT, FSH, insulin, and AST/ALT ratio were associated with sarcopenia and risk factors for low muscle mass. |
| first_indexed | 2024-04-11T13:54:19Z |
| format | Article |
| id | doaj.art-da38777052624264a2171bb3aad50977 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-11T13:54:19Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-da38777052624264a2171bb3aad509772022-12-22T04:20:27ZengBMCBMC Geriatrics1471-23182022-11-012211810.1186/s12877-022-03491-9Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopeniaMengting Yin0He Zhang1Qianhui Liu2Fei Ding3Lisha Hou4Yiping Deng5Tao Cui6Yixian Han7Yijun Chen8Chen Huang9Jirong Yue10Yong He11Department of Laboratory Medicine, West China Hospital, Sichuan UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityDepartment of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan UniversityDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityDepartment of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityAbstract Background: Sarcopenia is an age-related skeletal muscle disorder that involves a loss of muscle mass or strength and physiological function. Skeletal muscle deteriorates in both quantity and quality. The endocrine system is an important regulator of muscle metabolism. Therefore, we aimed to explore the relationship between biochemical markers and muscle mass in sarcopenia. Methods: We used the AWGS 2014 as the diagnostic criteria for sarcopenia, considering both the loss in muscle mass, muscle strength and physical performance. A total of 2837 elderly female participants over 50 years of age from the West China Health and Aging Trend (WCHAT) study were included. Insulin, glucose, 25(OH)VD, procalcitonin, alanine aminotransferase, aspartate aminotransferase, total protein, prealbumin, albumin, thyroid-stimulating hormone, free triiodothyronine, free tetraiodothyronine, triglycerides, cholesterol, high-density lipoprotein, very low-density lipoprotein, cortisol, and follicle-stimulating hormone were measured. Based on the findings of univariate analysis, multivariate regression and receiver operating characteristic (ROC) curves were established. Results: Participants with sarcopenia had significantly lower free triiodothyronine, insulin, total protein, albumin, prealbumin, albumin/prealbumin ratio (A/G), alanine aminotransferase, triglycerides, and very low-density lipoprotein concentrations (P < 0.05). Compared with those without sarcopenia, those with sarcopenia had significantly higher free tetraiodothyronine, cortisol, follicle-stimulating hormone (FSH), aspartate aminotransferase/alanine aminotransferase ratio (AST/ALT), and high-density lipoprotein concentrations (P < 0.05). Insulin (OR = 0.854), FSH (OR = 1.016), and the AST/ALT ratio (OR = 1.819) were independent risk factors for low muscle mass (P < 0.001). The AUC of insulin was the highest, followed by the AST/ALT ratio and FSH (0.691, 0.671, and 0.634, respectively), and the AUC of the mixture of the above three reached 0.736. Conclusion: In this cross-sectional study of elderly Chinese females aged over 50 years from the WCHAT, FSH, insulin, and AST/ALT ratio were associated with sarcopenia and risk factors for low muscle mass.https://doi.org/10.1186/s12877-022-03491-9SarcopeniaMuscle massFSHInsulinAST/ALT ratio |
| spellingShingle | Mengting Yin He Zhang Qianhui Liu Fei Ding Lisha Hou Yiping Deng Tao Cui Yixian Han Yijun Chen Chen Huang Jirong Yue Yong He Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia BMC Geriatrics Sarcopenia Muscle mass FSH Insulin AST/ALT ratio |
| title | Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia |
| title_full | Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia |
| title_fullStr | Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia |
| title_full_unstemmed | Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia |
| title_short | Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia |
| title_sort | determination of skeletal muscle mass by aspartate aminotransferase alanine aminotransferase ratio insulin and fsh in chinese women with sarcopenia |
| topic | Sarcopenia Muscle mass FSH Insulin AST/ALT ratio |
| url | https://doi.org/10.1186/s12877-022-03491-9 |
| work_keys_str_mv | AT mengtingyin determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT hezhang determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT qianhuiliu determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT feiding determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT lishahou determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT yipingdeng determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT taocui determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT yixianhan determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT yijunchen determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT chenhuang determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT jirongyue determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia AT yonghe determinationofskeletalmusclemassbyaspartateaminotransferasealanineaminotransferaseratioinsulinandfshinchinesewomenwithsarcopenia |