Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency

Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency

Common variable immunodeficiency (CVID) is characterized by profound primary antibody defects and frequent infections, yet autoimmune/inflammatory complications of unclear origin occur in 50% of individuals and lead to increased mortality. Here, we show that circulating bacterial 16S rDNA belonging...

Full description

Bibliographic Details
Main Authors: Hsi-en Ho, Lin Radigan, Gerold Bongers, Ahmed El-Shamy, Charlotte Cunningham-Rundles
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-10-01
Series:JCI Insight
Subjects:
Immunology
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.144777

Similar Items

Similar Items